INT315169

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.84 Pain Relevance 0

nucleus (Egfr, PCNA) cytoplasm (Egfr, PCNA) cell proliferation (Egfr, PCNA) nucleoplasm (PCNA) DNA binding (PCNA) plasma membrane (Egfr)

Egfr (Mus musculus) PCNA (Homo sapiens)

Pain Link Frequency Relevance Heat positron emission tomography 8 5.00 ketamine 1 5.00 anesthesia 1 5.00 isoflurane 1 5.00 imagery 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Cancer 39 96.16 Apoptosis 22 90.60 Death 4 84.92 Lung Cancer 27 75.00 Non-small-cell Lung Cancer 13 59.28 Advanced Or Metastatic Breast Cancer 2 55.24 Immunotherapy Of Cancer 1 47.88 Metastasis 1 43.28 Solid Tumor 2 5.00 Body Weight 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also demonstrate that lapatinib altered EGFR/HER-2 signaling pathways reducing p-EGFR, p-HER-2, p-ERK1/2, p-AKT, c-Myc and PCNA levels.

EGFR Negative_regulation (reducing) of PCNA

1) Confidence 0.03 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2883966 Disease Relevance 0.84 Pain Relevance 0

General Comments

This test has worked.