INT315178

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc25a2) mitochondrion (Slc25a2) molecular_function (Slc25a2)
biological_process (Slc25a2)
Slc25a2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 9 99.98 Very High Very High Very High
Opioid 10 99.76 Very High Very High Very High
Pain 7 99.28 Very High Very High Very High
opioid receptor 11 98.70 Very High Very High Very High
tolerance 26 97.68 Very High Very High Very High
mu opioid receptor 40 90.80 High High
Morphine 38 88.80 High High
narcan 35 87.76 High High
Spinal cord 18 80.32 Quite High
Antinociceptive 29 65.80 Quite High
Disease Link Frequency Relevance Heat
Pain 9 99.28 Very High Very High Very High
Targeted Disruption 10 51.56 Quite High
Injury 3 5.00 Very Low Very Low Very Low
Substance Withdrawal Syndrome 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Vomiting 2 5.00 Very Low Very Low Very Low
Respiratory Failure 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Constipation 1 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present data further support our previous findings in ICR mice [3] and suggest that, if the mutant opioid receptor can be delivered to the pain related pathway, opioid antagonist mediated activation of this mutant receptor should result in pain relieve without the development of tolerance.
Positive_regulation (mediated) of Positive_regulation (activation) of mutant receptor associated with pain, antagonist, tolerance, opioid receptor and opioid
1) Confidence 0.01 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2883971 Disease Relevance 0.25 Pain Relevance 2.37

General Comments

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