INT315181

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Mors1 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 40 100.00 Very High Very High Very High
narcan 35 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
Antinociceptive 29 99.48 Very High Very High Very High
Spinal cord 18 99.00 Very High Very High Very High
tolerance 26 98.24 Very High Very High Very High
MU agonist 2 91.12 High High
Pain management 1 89.52 High High
Morphine 38 88.20 High High
opioid receptor 11 84.80 Quite High
Disease Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
Substance Withdrawal Syndrome 2 78.00 Quite High
Targeted Disruption 10 69.12 Quite High
Injury 3 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Vomiting 2 5.00 Very Low Very Low Very Low
Respiratory Failure 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Constipation 1 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo transfecting the MORS196A gene into the pain related nervous pathway and systemically administering naloxone activated the local expressed mutant MOR and induced antinociceptive effect without tolerance.
Gene_expression (transfecting) of MORS196A gene Positive_regulation (activated) of MOR associated with pain, tolerance, mu opioid receptor, narcan and antinociceptive
1) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2883971 Disease Relevance 0.48 Pain Relevance 1.64

General Comments

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