INT315187

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SFRP1) extracellular space (SFRP1) extracellular region (SFRP1)
proteinaceous extracellular matrix (SFRP1) plasma membrane (SFRP1) intracellular (SFRP1)
Anatomy Link Frequency
lung 1
SFRP1 (Homo sapiens)
COPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 4 43.20 Quite Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Radiation Pneumonitis 288 100.00 Very High Very High Very High
Pulmonary Disease 32 100.00 Very High Very High Very High
Nicotine Addiction 12 83.80 Quite High
Lung Cancer 48 75.00 Quite High
Non-small-cell Lung Cancer 36 68.08 Quite High
Diabetes Mellitus 8 59.12 Quite High
Dyspnea 8 44.20 Quite Low
Angina 4 43.20 Quite Low
Fever 8 42.72 Quite Low
Cough 8 42.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, (I) in our study, we only found that COPD and FEV1 were significantly associated with SARP (p < 0.05), suggesting that the pulmonary function before radiotherapy and base-line pulmonary disease is critical for patients' well being after chemoradiotherapy.
SARP Binding (associated) of COPD associated with radiation pneumonitis and pulmonary disease
1) Confidence 0.01 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2883984 Disease Relevance 1.16 Pain Relevance 0
In our study, although the univariate analyses show that NTCP, MLD, V5-V60, COPD and FEV1 were associated with SARP (p < 0.05) however in multivariate analysis, only NTCP (p = 0.001) and V10 (p = 0.015) were found to be the significant factors associated with SARP statistically; the incidences of SARP in the group with NTCP > 4.2% and NTCP ?
SARP Binding (associated) of COPD associated with radiation pneumonitis and pulmonary disease
2) Confidence 0.01 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2883984 Disease Relevance 1.02 Pain Relevance 0
However, COPD and FEV1 were significant associated with SARP (p < 0.05) (Table 1).
SARP Binding (associated) of COPD associated with radiation pneumonitis and pulmonary disease
3) Confidence 0.01 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2883984 Disease Relevance 1.15 Pain Relevance 0
Univariate analyses showed that the normal tissue complication probability (NTCP), mean lung dose (MLD), relative volumes of lung receiving more than a threshold dose of 5-60 Gy at increments of 5 Gy (V5-V60), chronic obstructive pulmonary disease (COPD) and Forced Expiratory Volume in the first second (FEV1) were associated with SARP (p < 0.05).
SARP Binding (associated) of COPD in lung associated with radiation pneumonitis and pulmonary disease
4) Confidence 0.01 Published 2010 Journal Radiat Oncol Section Abstract Doc Link PMC2883984 Disease Relevance 1.14 Pain Relevance 0

General Comments

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