INT315259

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gcat) plasma membrane (Nfe2l2) nucleus (Nfe2l2)
molecular_function (Gcat) DNA binding (Nfe2l2) biological_process (Gcat)
Nfe2l2 (Mus musculus)
Gcat (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 1 31.84 Quite Low
Paracetamol 4 30.48 Quite Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 23 93.20 High High
Death 3 81.28 Quite High
Necrosis 1 63.12 Quite High
Apoptosis 3 62.64 Quite High
Injury 5 38.48 Quite Low
Acute Liver Failure 1 35.80 Quite Low
Overdose 1 33.48 Quite Low
Toxicity 17 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under basal conditions, Nrf2 is sequestered by Keap1 in the cytoplasm [7], and is constitutively targeted for ubiquitination by the Cul3-dependent E3 ubiquitin ligase complex, which results in its subsequent proteasomal degradation [8].
Nrf2 Binding (targeted) of ligase
1) Confidence 0.00 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.52 Pain Relevance 0

General Comments

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