INT315262

Context Info Confidence 0.30 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.48 Pain Relevance 0

nucleus (Keap1, Nfe2l2) cytoplasm (Keap1, Nfe2l2) endoplasmic reticulum (Keap1) plasma membrane (Nfe2l2) DNA binding (Nfe2l2)

Keap1 (Mus musculus) Nfe2l2 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 4 5.00 Inflammatory response 2 5.00 Analgesic 1 5.00 Inflammation 1 5.00 adenocard 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 5 97.88 Toxicity 17 92.36 Stress 23 65.68 Injury 5 5.00 Apoptosis 3 5.00 Death 3 5.00 INFLAMMATION 3 5.00 Overdose 1 5.00 Necrosis 1 5.00 Hepatocellular Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In line with this we have shown that the expression of Nrf2 was reduced by the co-depletion of Keap1 and p65 (Fig. 7).

Negative_regulation (depletion) of Keap1 Negative_regulation (reduced) of Gene_expression (expression) of Nrf2

1) Confidence 0.30 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.48 Pain Relevance 0

General Comments

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