INT31528

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.83
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYR) cell proliferation (TYR) lysosome (TYR)
cytoplasm (TYR)
Anatomy Link Frequency
melanocytes 3
paw 1
brain 1
TYR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 98.90 Very High Very High Very High
opiate 4 98.66 Very High Very High Very High
analgesia 5 98.48 Very High Very High Very High
Dopamine 2 97.56 Very High Very High Very High
Morphine 4 97.20 Very High Very High Very High
Acute pain 1 96.00 Very High Very High Very High
depression 2 95.24 Very High Very High Very High
tail-flick 1 94.12 High High
melanocortin 1 receptor 14 93.40 High High
Opioid 3 92.20 High High
Disease Link Frequency Relevance Heat
Skin Cancer 4 98.60 Very High Very High Very High
Stress 20 97.56 Very High Very High Very High
Pain 2 96.00 Very High Very High Very High
Depression 2 95.24 Very High Very High Very High
Amelanotic Melanoma 1 47.40 Quite Low
Metastasis 4 8.40 Low Low
Cancer 92 7.96 Low Low
Squamous Cell Carcinoma 5 7.72 Low Low
Apoptosis 34 5.00 Very Low Very Low Very Low
Death 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effects of the Tyr-MIF-1 peptides (all in dose 1 mg/kg i.p.) in the male Wistar rats on morphine-induced analgesia in acute pain using the paw-pressure (PP) and the tail-flick (TF) tests and on immobilization stress-induced antinociception using the PP test.
Spec (examined) Regulation (effects) of Tyr in paw associated with stress, antinociception, acute pain, tail-flick, analgesia and morphine
1) Confidence 0.44 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15632952 Disease Relevance 0.41 Pain Relevance 1.50
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands.
Regulation (Alteration) of tyrosinase in melanocytes associated with skin cancer
2) Confidence 0.27 Published 1994 Journal Melanoma Res. Section Title Doc Link 7535606 Disease Relevance 0.32 Pain Relevance 0.23
The results suggest that one or more NHEs may help regulate melanosome pH and tyrosinase activity in human melanocytes.
Regulation (regulate) of tyrosinase in melanocytes
3) Confidence 0.25 Published 2004 Journal Exp. Cell Res. Section Abstract Doc Link 15265699 Disease Relevance 0 Pain Relevance 0.07
Treatment of human melanocytes with 1 nM-10 nM recombinant mouse or human ASIP blocked the stimulatory effects of alpha-MSH on cAMP accumulation, tyrosinase activity, and cell proliferation.
Regulation (effects) of tyrosinase in melanocytes
4) Confidence 0.23 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9182807 Disease Relevance 0 Pain Relevance 0.53
To assess possible interactions between endogenous opiate antagonists and benzodiazepine receptor binding, we evaluated the effects of the peptides MIF-1 and Tyr-MIF-1 on benzodiazepine receptor binding in mouse brain membranes.
Regulation (effects) of Tyr in brain associated with antagonist and opiate
5) Confidence 0.19 Published 1987 Journal Peptides Section Abstract Doc Link 2893356 Disease Relevance 0 Pain Relevance 0.49
In the absence of exogenous alpha-MSH, ASIP inhibited basal levels of tyrosinase activity and cell proliferation and reduced the level of immunoreactive tyrosinase-related protein-1 (TRP-1) without significantly altering the level of immunoreactive tyrosinase.
Neg (without) Regulation (altering) of tyrosinase
6) Confidence 0.14 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9182807 Disease Relevance 0 Pain Relevance 0.51
mol/L [133,130], whereas tyrosinase and tyrosine decarboxylase are not influenced by 1 to 10 ?
Neg (not) Regulation (influenced) of tyrosinase
7) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.10 Pain Relevance 0.30

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