INT315284

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PRKG1, Nos1) cytosol (PRKG1, Nos1) plasma membrane (PRKG1, Nos1)
mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
Anatomy Link Frequency
neuronal 1
PRKG1 (Homo sapiens)
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 2 99.40 Very High Very High Very High
Neuropathic pain 9 97.84 Very High Very High Very High
Spinal cord 26 93.64 High High
Hyperalgesia 10 92.88 High High
Peripheral nerve injury 3 90.72 High High
excitatory amino acid 1 87.84 High High
qutenza 2 87.64 High High
IPN 8 86.76 High High
spinal dorsal horn 7 85.76 High High
Dorsal horn 2 83.60 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 36 97.84 Very High Very High Very High
Hyperalgesia 10 92.88 High High
Nervous System Injury 7 89.84 High High
Inflammatory Pain 8 86.76 High High
Hypersensitivity 1 63.52 Quite High
Pain 41 59.96 Quite High
Cv Unclassified Under Development 14 50.00 Quite Low
Injury 21 29.72 Quite Low
INFLAMMATION 4 20.40 Low Low
Complex Regional Pain Syndromes 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, Xu et al. [27] reported that NO, as a retrograde messenger, released glutamate through the presynaptic cGMP-PKG pathway and increased the neuronal NO synthase (nNOS) activity; then NO itself increased NO generation to neuropathic pain along with continued afferent stimuli.
PKG Positive_regulation (increased) of nNOS in neuronal associated with glutamate and neuropathic pain
1) Confidence 0.33 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2884210 Disease Relevance 0.85 Pain Relevance 1.56

General Comments

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