INT315334

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.85
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CYP3A4, CDIPT) small molecule metabolic process (CYP3A4) oxidoreductase activity (CYP3A4)
Golgi apparatus (CDIPT) plasma membrane (CDIPT) enzyme binding (CYP3A4)
CYP3A4 (Homo sapiens)
CDIPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 58 92.00 High High
methadone 91 91.28 High High
Opioid 34 90.40 High High
addiction 11 62.92 Quite High
cocaine 8 54.20 Quite High
Pain 16 45.20 Quite Low
drug abuse 1 39.00 Quite Low
tricyclic antidepressant 2 24.12 Low Low
opiate 9 22.92 Low Low
withdrawal 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 43 87.00 High High
Reprotox - General 2 56 71.72 Quite High
Opiate Addiction 12 62.92 Quite High
Toxicity 24 55.76 Quite High
Death 1 53.04 Quite High
Recurrence 1 52.00 Quite High
Drug Dependence 2 39.00 Quite Low
Pain 14 29.96 Quite Low
Disease 4 16.20 Low Low
Infection 1 8.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, the nonnucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs), which form the backbone of highly active antiretroviral therapy, are all metabolized by (ie, are substrates of) the CYP450 enzymes, most by CYP3A4.
CYP3A4 Binding (metabolized) of PIs
1) Confidence 0.04 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2892618 Disease Relevance 0.25 Pain Relevance 0.59
In examining the PIs affinity for CYP450 enzymes, lopinavir is a substrate of the enzyme CYP3A4, while ritonavir is a substrate of CYP1A2, 2B6, 2D6, and 3A4.
CYP3A4 Binding (affinity) of PIs
2) Confidence 0.04 Published 2010 Journal Int J Emerg Med Section Body Doc Link PMC2885261 Disease Relevance 0.30 Pain Relevance 0
In examining the PIs affinity for CYP450 enzymes, lopinavir is a substrate of the enzyme CYP3A4, while ritonavir is a substrate of CYP1A2, 2B6, 2D6, and 3A4.
CYP3A4 Binding (affinity) of PIs
3) Confidence 0.04 Published 2010 Journal Int J Emerg Med Section Body Doc Link PMC2885261 Disease Relevance 0.30 Pain Relevance 0

General Comments

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