INT315353

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle fibers 1
microglia 1
H2-K1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 4 98.20 Very High Very High Very High
Inflammation 38 86.48 High High
cytokine 4 81.60 Quite High
gABA 2 27.88 Quite Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Sciatic nerve 11 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 1 5.00 Very Low Very Low Very Low
Peripheral nerve injury 1 5.00 Very Low Very Low Very Low
dorsal root ganglion 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 17 99.96 Very High Very High Very High
INFLAMMATION 33 98.20 Very High Very High Very High
Stress 28 95.60 Very High Very High Very High
Injury 9 91.04 High High
Myositis 42 79.60 Quite High
Parasitic Infection 1 43.00 Quite Low
Targeted Disruption 11 41.44 Quite Low
Muscle Disease 1 38.64 Quite Low
Muscular Dystrophy 1 32.08 Quite Low
Apoptosis 3 25.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the microglial reaction in our study did not differ between the two mice strains, MHC I protein was co-localized with the Iba-1 marker, indicating that microglia upregulate such molecules soon after axotomy.
Localization (localized) of MHC I in microglia associated with sprains and strains
1) Confidence 0.30 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.34 Pain Relevance 0.06
Interestingly, a single LPS injection increased significantly Grp75 protein levels in skeletal muscle fibers, in the absence of both Grp94 [24] and MHC-I upregulation (present manuscript), proving that systemic inflammatory stimuli do raise the expression of this antioxidant stress-protein in muscle fibers.
Localization (upregulation) of MHC-I in muscle fibers associated with stress and inflammatory stimuli
2) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.94 Pain Relevance 0.25

General Comments

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