INT315354

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.02
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Etv5) DNA binding (Etv5)
Anatomy Link Frequency
spinal cord 1
epithelial cell 1
Etv5 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 12 99.84 Very High Very High Very High
Inflammation 5 83.44 Quite High
Sciatic nerve 11 58.52 Quite High
Neuropathic pain 1 52.96 Quite High
dorsal root ganglion 1 45.88 Quite Low
ketamine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 328 100.00 Very High Very High Very High
Sprains And Strains 13 97.84 Very High Very High Very High
INFLAMMATION 6 83.44 Quite High
Targeted Disruption 34 69.52 Quite High
Metastasis 4 68.84 Quite High
Wallerian Degeneration 1 66.40 Quite High
Optic Nerve Injuries 1 56.36 Quite High
Neuropathic Pain 1 52.96 Quite High
Carcinoma 28 50.00 Quite Low
Ganglion Cysts 1 45.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown by qPCR analysis, expression of known regulators of normal and tumor mammary epithelial cell fate and function, namely Ehf [43], Elf5 [44], Etv5 [45], and Foxc1 [46] is stronger in the CD24ahigh subset (Figure 13B), whereas the CD24alow subset is distinguished by a higher expression of the Twist2 gene (Figure 13B), whose product has a function in EMT [38].
Gene_expression (expression) of Etv5 in epithelial cell associated with cancer
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.26 Pain Relevance 0
Interestingly, A/J mice, which present a greater axonal regeneration potential [27,28], also display more robust glial fibrillary acidic (GFAP) and ERM (ezrin-radixin-miosin) protein expression in spinal cord after axotomy, when compared to other strains of mice [24-26].
Gene_expression (expression) of ERM in spinal cord associated with sprains and strains and spinal cord
2) Confidence 0.23 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.43 Pain Relevance 0.21
Cd24a, Cd49f, Sca1, and do express, though at different levels, the transcription factors associated with epithelial (e.g., Ehf, Etv5 and Elf5) and mesenchymal (e.g., Twist2) differentiation gene expression programs.
Gene_expression (express) of Etv5
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.34 Pain Relevance 0

General Comments

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