INT315355

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.66
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 2
peripheral nerve 2
H2-K1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 48 99.46 Very High Very High Very High
Inflammation 12 94.68 High High
Peripheral nerve injury 4 94.52 High High
cytokine 8 87.76 High High
Sciatic nerve 44 86.28 High High
Inflammatory stimuli 4 84.04 Quite High
Neuropathic pain 4 63.92 Quite High
gABA 8 55.28 Quite High
Neuronal nitric oxide synthase 4 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 40 99.12 Very High Very High Very High
INFLAMMATION 16 94.68 High High
Nervous System Injury 4 94.52 High High
Sprains And Strains 52 92.56 High High
Body Weight 4 86.48 High High
Injury 32 85.60 High High
Parasitic Infection 4 70.40 Quite High
Death 4 67.88 Quite High
Neuropathic Pain 4 63.92 Quite High
Wallerian Degeneration 4 57.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results are consistent with this hypothesis, since iNOS-/- mice displayed significantly reduced expression of MHC I one and two weeks after lesioning.
Negative_regulation (reduced) of Gene_expression (expression) of MHC I
1) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.30 Pain Relevance 0.15
It is proposed that iNOS expression influences the outcome of the synaptic plasticity process in spinal cord, which is correlated with reduced MHC I expression.


Negative_regulation (reduced) of Gene_expression (expression) of MHC I in spinal cord associated with spinal cord
2) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.53 Pain Relevance 0.24
In conclusion, the present study shows that knockout mice for the inducible form of NOS display decreased expression of MHC I after lesioning and greater synaptic elimination after peripheral axotomy.
Negative_regulation (decreased) of Gene_expression (expression) of MHC I associated with targeted disruption
3) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.46 Pain Relevance 0.13
This is relevant to the regenerative outcome because C57BL6/J mice, which express reduced amounts of classical MHC I compared to A/J animals, show decreased axonal growth in regenerating peripheral nerve and a delayed return of peripheral nerve function [26].
Negative_regulation (reduced) of Gene_expression (express) of MHC I in peripheral nerve
4) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.37 Pain Relevance 0.12

General Comments

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