INT31541

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 1987
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 4.12
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1) nucleus (Esr1) enzyme binding (Esr1)
DNA binding (Esr1) protein complex (Esr1) transcription factor binding (Esr1)
Anatomy Link Frequency
brain 2
blood 1
thyroid 1
uterine 1
fundus 1
Esr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 34 100.00 Very High Very High Very High
Peripheral sensitization 1 99.84 Very High Very High Very High
Pain 7 97.84 Very High Very High Very High
Hippocampus 32 97.12 Very High Very High Very High
anesthesia 19 96.20 Very High Very High Very High
allodynia 2 95.76 Very High Very High Very High
opiate 5 95.12 Very High Very High Very High
narcan 2 92.20 High High
antagonist 15 91.68 High High
Trigeminal ganglion neurons 2 91.64 High High
Disease Link Frequency Relevance Heat
Osteomyelitis 296 99.00 Very High Very High Very High
Breast Cancer 7 98.36 Very High Very High Very High
Pain 4 97.84 Very High Very High Very High
Neuropathic Pain 2 95.76 Very High Very High Very High
Cancer 8 92.48 High High
Stress 38 92.44 High High
Ganglion Cysts 2 91.20 High High
Wound Healing 136 90.32 High High
INFLAMMATION 34 88.52 High High
Temporomandibular Joint Syndrome 46 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further evidence of noradrenergic regulation of rat hypothalamic estrogen receptor concentration: possible non-functional increase and functional decrease.
Regulation (regulation) of hypothalamic estrogen receptor
1) Confidence 0.54 Published 1987 Journal Brain Res. Section Title Doc Link 2893651 Disease Relevance 0 Pain Relevance 0.18
Down-regulation of estrogen receptor was suggested to involve some transcriptional activation mechanisms such as proteasome-mediated proteolysis activity [45,46].


Regulation (regulation) of estrogen receptor
2) Confidence 0.41 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2811708 Disease Relevance 0.30 Pain Relevance 0.25
Previous evidence supports the notion of competitive DNA binding and protein/protein interactions providing mechanisms for nuclear thyroid hormone receptors to affect estrogen receptor function, but other, additional mechanisms cannot be ruled out.
Regulation (affect) of estrogen receptor in thyroid
3) Confidence 0.29 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10516479 Disease Relevance 0.06 Pain Relevance 0.10
Our results indicated that anesthetic agents affected the ESR.
Regulation (affected) of ESR
4) Confidence 0.23 Published 2006 Journal Clin. Hemorheol. Microcirc. Section Abstract Doc Link 17148844 Disease Relevance 0 Pain Relevance 0.25
ESR values of the second blood samples were significantly lower than the first values (p<0.001).
Regulation (values) of ESR in blood
5) Confidence 0.23 Published 2006 Journal Clin. Hemorheol. Microcirc. Section Abstract Doc Link 17148844 Disease Relevance 0 Pain Relevance 0.24
Role of the oestrogen receptors GPR30 and ERalpha in peripheral sensitization: relevance to trigeminal pain disorders in women.
Regulation (Role) of ERalpha associated with pain, inflammation and peripheral sensitization
6) Confidence 0.21 Published 2009 Journal Cephalalgia Section Title Doc Link 19220308 Disease Relevance 0.48 Pain Relevance 0.75
ESR values and MRI scan may help to identify osteomyelitis patients and differentiate acute and subacute osteomyelitis.



Regulation (values) of ESR associated with osteomyelitis
7) Confidence 0.16 Published 2008 Journal BMC Pediatr Section Abstract Doc Link PMC2588573 Disease Relevance 1.44 Pain Relevance 0
In other studies, ESR was elevated in 88% to 92% of osteomyelitis patients on admission, and the rate of positive test and median or mean ESR value depended on whether there patients had the acute, subacute or chronic form.[4,37] The fact that an ESR ?
Regulation (value) of ESR associated with osteomyelitis
8) Confidence 0.16 Published 2008 Journal BMC Pediatr Section Body Doc Link PMC2588573 Disease Relevance 1.21 Pain Relevance 0.06
An Eco RI fragment of 1.9 kb containing the whole open reading frame of the mouse estrogen receptor ?
Regulation (containing) of estrogen receptor
9) Confidence 0.16 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
Its success has been attributed to the modulation of the estrogen receptor.
Regulation (modulation) of estrogen receptor
10) Confidence 0.07 Published 2003 Journal BMC Cancer Section Abstract Doc Link PMC212317 Disease Relevance 0.19 Pain Relevance 0.03
Recent evidence indicates that environmental enrichment (EE) improves the attachment behavior of rat dams toward their pups, and that this is likely mediated through the effects of EE on the estrogen receptor and its modulation of oxytocin brain levels. [1].
Regulation (effects) of estrogen receptor in brain
11) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677672 Disease Relevance 0.18 Pain Relevance 0.12
Recent evidence indicates that environmental enrichment (EE) improves the attachment behavior of rat dams toward their pups, and that this is likely mediated through the effects of EE on the estrogen receptor and its modulation of oxytocin brain levels. [1].
Regulation (modulation) of estrogen receptor in brain
12) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677672 Disease Relevance 0.18 Pain Relevance 0.12
There were no topology-, gestation- or labor-related changes of ER alpha and PR mRNA in or between the lower uterine segment or/and the fundus.
Regulation (changes) of ER alpha in fundus
13) Confidence 0.02 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11739010 Disease Relevance 0 Pain Relevance 0
No age-related changes in estrogen receptor concentrations were observed in any tissue except the anterior pituitary in which binding increased 3.2-fold between 2 and 10 wk.
Regulation (changes) of estrogen receptor in anterior pituitary
14) Confidence 0.02 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8094980 Disease Relevance 0.08 Pain Relevance 0.64
In conclusion, fundal and lower uterine segment ER alpha and PR mRNA remained unchanged in late gestation and spontaneous labor.
Neg (unchanged) Regulation (unchanged) of ER alpha in uterine
15) Confidence 0.02 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11739010 Disease Relevance 0 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox