INT315427

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.33 Pain Relevance 0.50

cell differentiation (Uhrf2) cell proliferation (Uhrf2) histone binding (Uhrf2) nucleus (Uhrf2) cell cycle (Uhrf2) DNA binding (Uhrf2)

Anatomy Link Frequency brain 1 Uhrf2 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 56 99.96 anesthesia 3 99.90 ischemia 4 91.84 isoflurane 3 81.56 Deep tissue 2 5.00 Arthritis 1 5.00

Disease Link Frequency Relevance Heat Cv General 4 Under Development 4 92.56 Cancer 4 91.36 Middle Cerebral Artery Infarction 1 76.72 Stroke 4 71.48 Disease 5 6.48 Graft Vs Host Disease 17 5.00 Targeted Disruption 3 5.00 Animal Disease Models 2 5.00 Brain Disease 2 5.00 Myelodysplastic Syndromes 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Co-cultured Thy1.1+ cells showed no increase in NIRF (Fig. 1E).

Neg (no) Positive_regulation (increase) of NIRF

1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885427 Disease Relevance 0 Pain Relevance 0.10

NIRF imaging was performed 2 h after injection of Cy5.5-albumin and the brain was then removed from the skull under deep anesthesia and used for ex vivo NIRF imaging [Fig. 4

Positive_regulation (used) of NIRF in brain associated with anesthesia and imagery

2) Confidence 0.29 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3005168 Disease Relevance 0.33 Pain Relevance 0.40

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