INT315470

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2007
Negated 5
Speculated 1
Reported most in Body
Documents 1
Total Number 54
Disease Relevance 23.81
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Slfn5) nucleus (Slfn5)
Anatomy Link Frequency
HeLa 2
plaque 2
fibroblasts 1
immune system 1
Slfn5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 108 76.00 Quite High
lidocaine 54 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Contagious Ecthyma 216 100.00 Very High Very High Very High
Sprains And Strains 1890 99.98 Very High Very High Very High
Influenza Virus Infection 216 99.84 Very High Very High Very High
Infection 1242 99.68 Very High Very High Very High
Weight Loss 54 97.28 Very High Very High Very High
Pox Virus Infection 324 96.84 Very High Very High Very High
Body Weight 54 85.04 High High
INFLAMMATION 108 76.00 Quite High
Targeted Disruption 54 43.88 Quite Low
Monkeypox 54 30.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B8R to provide a second attenuating mutation (Buller et al., 1985). v-slfn was expressed either without (v176-WT) or with an N- or C-terminal HA tag (v176-NHA and v176-CHA, respectively) under the control of a synthetic early and late promoter. v-slfn expression by these viruses was observed from 2?
Neg (without) Gene_expression (expressed) of v-slfn
1) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.45 Pain Relevance 0
Construction of recombinant VACV expressing CMLV v-slfn
Gene_expression (expressing) of v-slfn
2) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.76 Pain Relevance 0
4f), showing co-staining with these two Abs. v-slfn localization was also analysed in NIH3T3 cell lines expressing v-slfn using an ?
Gene_expression (expressing) of v-slfn
3) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.14 Pain Relevance 0
Similarly, VACV plaque morphology and size were unaltered by expression of v-slfn in BS-C-1 (Supplementary Fig.
Gene_expression (expression) of v-slfn in plaque
4) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.23 Pain Relevance 0
Recombinant viruses expressing wild-type v-slfn or v-slfn tagged at its C terminus with a haemagglutinin (HA) epitope were less virulent than control viruses.
Gene_expression (expressing) of v-slfn
5) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Abstract Doc Link PMC2885618 Disease Relevance 0.52 Pain Relevance 0
A VACV strain expressing full-length v-slfn was not identified, therefore the function of v-slfn was studied using a recombinant VACV expressing the CMLV v-slfn.
Gene_expression (expressing) of v-slfn associated with sprains and strains
6) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.68 Pain Relevance 0
Consistent with this, all 16 VACV strains tested do not express a v-slfn detected by polyclonal serum raised against the CMLV protein.
Neg (not) Gene_expression (express) of v-slfn associated with sprains and strains
7) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Abstract Doc Link PMC2885618 Disease Relevance 0.56 Pain Relevance 0
B8R was used as the parental virus for construction of recombinant VACV expressing WT v-slfn, HA-tagged v-slfn or influenza virus HA from the TK locus.
Gene_expression (expressing) of v-slfn associated with influenza virus infection
8) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.10 Pain Relevance 0
Recombinant viruses expressing wild-type v-slfn or v-slfn tagged at its C terminus with a haemagglutinin (HA) epitope were less virulent than control viruses.
Gene_expression (expressing) of v-slfn
9) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Abstract Doc Link PMC2885618 Disease Relevance 0.52 Pain Relevance 0
Thus, v-slfn is an early and late protein that is encoded by a full-length ORF in several OPVs, but is not expressed by any of the 16 VACV strains tested, suggesting that it is either absent or broken into smaller ORFs, as is the case for VACV strains Copenhagen (COP) and WR.


Neg (not) Gene_expression (expressed) of v-slfn associated with sprains and strains and contagious ecthyma
10) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 1.03 Pain Relevance 0
However, a virus expressing v-slfn tagged with the HA epitope at its N terminus had similar virulence to controls, implying that the N terminus has an important function.
Gene_expression (expressing) of v-slfn
11) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Abstract Doc Link PMC2885618 Disease Relevance 0.49 Pain Relevance 0
Clone B7 was selected as the line exhibiting no basal v-slfn expression and the highest tetracycline inducibility.


Neg (no) Gene_expression (expression) of v-slfn
12) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0 Pain Relevance 0
A VACV strain expressing full-length v-slfn was not identified, therefore the function of v-slfn was studied using a recombinant VACV expressing the CMLV v-slfn.
Gene_expression (expressing) of v-slfn associated with sprains and strains
13) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.71 Pain Relevance 0
B8R was used as the parental virus for construction of recombinant VACV expressing WT v-slfn, HA-tagged v-slfn or influenza virus HA from the TK locus.
Gene_expression (expressing) of v-slfn associated with influenza virus infection
14) Confidence 0.18 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.10 Pain Relevance 0
B8R to provide a second attenuating mutation (Buller et al., 1985). v-slfn was expressed either without (v176-WT) or with an N- or C-terminal HA tag (v176-NHA and v176-CHA, respectively) under the control of a synthetic early and late promoter. v-slfn expression by these viruses was observed from 2?
Gene_expression (expression) of v-slfn
15) Confidence 0.15 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.43 Pain Relevance 0
-FLAG mAb (data not shown), and after transient transfection of HeLa cells with the mammalian expression vector pCI alone or pCI expressing v-slfn with or without an HA tag. v-slfn was visualized with either ?
Gene_expression (expressing) of v-slfn in HeLa
16) Confidence 0.15 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.21 Pain Relevance 0
To determine whether expression of v-slfn altered virus replication, the growth properties of v?
Gene_expression (expression) of v-slfn
17) Confidence 0.15 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.23 Pain Relevance 0
CMLV 176 protein (v-slfn) is most closely related to short m-slfns; however, when expressed stably in mammalian cells, v-slfn did not inhibit cell growth. v-slfn is a predominantly cytoplasmic 57 kDa protein that is expressed throughout infection.
Gene_expression (expressed) of v-slfn associated with infection
18) Confidence 0.15 Published 2007 Journal The Journal of General Virology Section Abstract Doc Link PMC2885618 Disease Relevance 0.46 Pain Relevance 0
-FLAG mAb (data not shown), and after transient transfection of HeLa cells with the mammalian expression vector pCI alone or pCI expressing v-slfn with or without an HA tag. v-slfn was visualized with either ?
Gene_expression (visualized) of v-slfn in HeLa
19) Confidence 0.15 Published 2007 Journal The Journal of General Virology Section Body Doc Link PMC2885618 Disease Relevance 0.21 Pain Relevance 0
CMLV 176 protein (v-slfn) is most closely related to short m-slfns; however, when expressed stably in mammalian cells, v-slfn did not inhibit cell growth. v-slfn is a predominantly cytoplasmic 57 kDa protein that is expressed throughout infection.
Gene_expression (expressed) of v-slfn associated with infection
20) Confidence 0.15 Published 2007 Journal The Journal of General Virology Section Abstract Doc Link PMC2885618 Disease Relevance 0.51 Pain Relevance 0

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