INT315533

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GLRX5, ALAS2) small molecule metabolic process (ALAS2) biosynthetic process (ALAS2)
nucleus (GLRX5) transferase activity, transferring acyl groups (ALAS2)
GLRX5 (Homo sapiens)
ALAS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 18 99.56 Very High Very High Very High
Porphyria 5 99.36 Very High Very High Very High
Repression 2 97.64 Very High Very High Very High
Stress 4 95.40 Very High Very High Very High
Iron Overload 24 94.08 High High
Diabetes Mellitus 2 59.52 Quite High
Disease 27 50.00 Quite Low
Sideroblastic Anemia 15 44.72 Quite Low
Cirrhosis 1 40.40 Quite Low
Ataxia 24 38.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GLRX5 knockdown activates IRPs and thereby decreases the level of ALAS2 expression and interrupts heme biosynthesis, but activated IRPs cannot repress FPN1b expression, which is induced during the stress response to mitochondrial iron overload and worsens cytosolic iron deficiency in eythroid cells (Figure 3).
Negative_regulation (knockdown) of GLRX5 Negative_regulation (decreases) of Gene_expression (expression) of ALAS2 associated with stress, anaemia, porphyria and iron overload
1) Confidence 0.38 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.06 Pain Relevance 0

General Comments

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