INT315541

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ACO1, ALAS2) small molecule metabolic process (ALAS2) lyase activity (ACO1)
Golgi apparatus (ACO1) endoplasmic reticulum (ACO1) transferase activity, transferring acyl groups (ALAS2)
ACO1 (Homo sapiens)
ALAS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 27 91.52 High High
Ataxia 24 39.08 Quite Low
Sideroblastic Anemia 15 38.64 Quite Low
Targeted Disruption 2 30.80 Quite Low
Anaemia 18 23.44 Low Low
Hematological Disease 1 18.60 Low Low
Iron Overload 24 5.00 Very Low Very Low Very Low
Muscle Disease 9 5.00 Very Low Very Low Very Low
Porphyria 5 5.00 Very Low Very Low Very Low
Syndrome 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IRP1 converts to its IRE-binding form and inhibits the expression of ALAS2 in heme synthesis.
IRP1 Negative_regulation (inhibits) of Gene_expression (expression) of ALAS2
1) Confidence 0.17 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.18 Pain Relevance 0

General Comments

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