INT315552

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GLRX5) nucleus (GLRX5)
GLRX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 36 99.56 Very High Very High Very High
Repression 4 97.64 Very High Very High Very High
Porphyria 10 96.68 Very High Very High Very High
Ataxia 48 92.80 High High
Stress 8 92.72 High High
Sideroblastic Anemia 30 92.36 High High
Iron Overload 48 91.40 High High
Muscle Disease 18 82.16 Quite High
Disease 54 74.24 Quite High
Parkinson's Disease 2 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of GLRX5 deficiency, although it has been shown that asymptomatic tissues also lack the GLRX5 protein, the primary phenotype is limited to erythroid cells.
Negative_regulation (lack) of GLRX5 protein
1) Confidence 0.38 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.14 Pain Relevance 0
The GLRX5 knockdown activates IRPs and thereby decreases the level of ALAS2 expression and interrupts heme biosynthesis, but activated IRPs cannot repress FPN1b expression, which is induced during the stress response to mitochondrial iron overload and worsens cytosolic iron deficiency in eythroid cells (Figure 3).
Negative_regulation (knockdown) of GLRX5 associated with stress, anaemia, porphyria and iron overload
2) Confidence 0.38 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.03 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox