INT315559

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome segregation (CIAO1)
CIAO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 54 100.00 Very High Very High Very High
Iron Overload 72 99.74 Very High Very High Very High
Stress 12 98.94 Very High Very High Very High
Porphyria 15 97.18 Very High Very High Very High
Repression 6 87.40 High High
Ataxia 72 78.48 Quite High
Diabetes Mellitus 6 75.44 Quite High
Sideroblastic Anemia 45 68.32 Quite High
Disease 81 66.96 Quite High
Protein Deficiency 3 65.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the iron exporter gene ferroportin (FPN1) is significantly upregulated, potentially exacerbating the cytosolic iron deficiency.
Negative_regulation (deficiency) of cytosolic iron associated with anaemia
1) Confidence 0.19 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.45 Pain Relevance 0
The fact that cytosolic iron depletion occurs in conjunction with mitochondrial iron overload may explain why cytosolic iron?
Negative_regulation (depletion) of cytosolic iron associated with iron overload
2) Confidence 0.19 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.79 Pain Relevance 0
The GLRX5 knockdown activates IRPs and thereby decreases the level of ALAS2 expression and interrupts heme biosynthesis, but activated IRPs cannot repress FPN1b expression, which is induced during the stress response to mitochondrial iron overload and worsens cytosolic iron deficiency in eythroid cells (Figure 3).
Negative_regulation (deficiency) of cytosolic iron associated with stress, anaemia, porphyria and iron overload
3) Confidence 0.19 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.29 Pain Relevance 0

General Comments

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