INT315562

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 4.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GLRX5) nucleus (GLRX5)
Anatomy Link Frequency
fibroblasts 2
skeletal muscles 1
hematopoietic cells 1
lymphoblasts 1
GLRX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 18 5.00 Very Low Very Low Very Low
Glutamate 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Protein Deficiency 9 100.00 Very High Very High Very High
Ataxia 216 99.80 Very High Very High Very High
Disease 243 99.56 Very High Very High Very High
Anaemia 162 99.56 Very High Very High Very High
Muscle Disease 81 98.74 Very High Very High Very High
Iron Overload 216 98.00 Very High Very High Very High
Friedreich Ataxia 18 95.20 Very High Very High Very High
Porphyria 45 93.36 High High
Sideroblastic Anemia 135 89.44 High High
Hyperplasia 9 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent rescue experiment of GLRX5 patient fibroblasts using a lentiviral vector that carries the wild-type GLRX5 gene sequence demonstrated that restored GLRX5 expression could improve cell growth, reverse mitochondrial iron overload, and increase aconitase activity (Figure 4) (32).
Gene_expression (expression) of GLRX5 in fibroblasts associated with iron overload
1) Confidence 0.69 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.88 Pain Relevance 0
It is also interesting that in fibroblasts and lymphoblasts from patients with Friedreich's ataxia (53) and glutaredoxin 5 deficiency (32), impaired mitochondrial iron?
Gene_expression (deficiency) of glutaredoxin 5 in lymphoblasts associated with ataxia
2) Confidence 0.65 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.80 Pain Relevance 0
In ISCU myopathy, only skeletal muscles and cardiac cells are affected, and in glutaredoxin 5 deficiency, the only disease manifestation is anemia (Table 1).
Gene_expression (deficiency) of glutaredoxin 5 in skeletal muscles associated with anaemia, muscle disease and disease
3) Confidence 0.65 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.11 Pain Relevance 0
A chaperone and cochaperone pair, known as HscA and HscB in bacteria or Ssq1 and Jac1 in yeast (20), respectively, along with a glutaredoxin, Grx5, are thought to facilitate the transfer of Fe?
Gene_expression (transfer) of Grx5
4) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0 Pain Relevance 0
Although GLRX5 knockdown affects both Fe?
Gene_expression (knockdown) of GLRX5
5) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.50 Pain Relevance 0
The GLRX5 protein deficiency results in a defect in Fe?
Gene_expression (deficiency) of GLRX5 protein associated with protein deficiency
6) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.41 Pain Relevance 0
GLRX5 may also function as a scaffold and may facilitate the transfer of Fe?
Gene_expression (transfer) of GLRX5
7) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0 Pain Relevance 0
Western blotting confirms that the GLRX5 protein is absent in multiple tissues of the patient, including hematopoietic cells (e.g., lymphoblast) and nonhematopoietic cells (e.g., fibroblast) (32).
Neg (absent) Gene_expression (absent) of GLRX5 protein in hematopoietic cells
8) Confidence 0.53 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.42 Pain Relevance 0
It is also interesting that in fibroblasts and lymphoblasts from patients with Friedreich's ataxia (53) and glutaredoxin 5 deficiency (32), impaired mitochondrial iron?
Gene_expression (deficiency) of glutaredoxin 5 in fibroblasts associated with ataxia
9) Confidence 0.22 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.80 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox