INT315563

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 5.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FXN) mitochondrion (FXN) mitochondrion organization (FXN)
enzyme binding (FXN) cytoplasm (FXN)
Anatomy Link Frequency
lymphocytes 2
FXN (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 8 5.00 Very Low Very Low Very Low
Lasting pain 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 32 99.72 Very High Very High Very High
Iron Overload 96 96.80 Very High Very High Very High
Ataxia 188 94.36 High High
Targeted Disruption 60 89.96 High High
Embryonic Lethality 12 89.24 High High
Disease 160 88.88 High High
Cold Sores 72 88.64 High High
Sideroblastic Anemia 60 87.12 High High
Porphyria 20 83.44 Quite High
Neurodegenerative Disease 16 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that the FRDA-BAC contains all the regulatory elements needed for the FRDA gene to be expressed in a physiological fashion.
Positive_regulation (needed) of Gene_expression (expressed) of FRDA
1) Confidence 0.41 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.64 Pain Relevance 0
However, the nonphysiological overexpression of frataxin driven by these vectors has been shown to be cytopathological.
Positive_regulation (overexpression) of Gene_expression (overexpression) of frataxin
2) Confidence 0.41 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.63 Pain Relevance 0
After 8 weeks of treatment, only two patients experienced a net increment in frataxin levels in peripheral blood lymphocytes, patients who also showed a reduction in markers of oxidative stress.
Positive_regulation (increment) of Gene_expression (levels) of frataxin in lymphocytes associated with stress
3) Confidence 0.36 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.95 Pain Relevance 0
As mentioned above, it seems that optimal frataxin levels are required for correct cell function, since both deficiency and massive overexpression are associated with cell pathology.
Positive_regulation (overexpression) of Gene_expression (overexpression) of frataxin
4) Confidence 0.36 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.68 Pain Relevance 0
sulfur cluster biogenesis results in remodeling of iron metabolism, and loss of frataxin and loss of Atm1 both result in a markedly reduced level of transcription of Leu1 (108), the cytosolic iron?
Positive_regulation (result) of Gene_expression (loss) of frataxin
5) Confidence 0.25 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.39 Pain Relevance 0
Moreover, in a yeast model of frataxin deficiency, iron is mobilized from the iron overloaded mitochondria within minutes after normal frataxin expression is restored (105).
Positive_regulation (normal) of Gene_expression (expression) of frataxin
6) Confidence 0.25 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.51 Pain Relevance 0
Under normal conditions in adult tissues, FXN is localized to the mitochondria, while under oxidative stress, a cytosolic FXN has been observed which may facilitate the regeneration of Fe?
Spec (may) Positive_regulation (facilitate) of Gene_expression (observed) of FXN associated with stress
7) Confidence 0.25 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.74 Pain Relevance 0
Moreover, in a yeast model of frataxin deficiency, iron is mobilized from the iron overloaded mitochondria within minutes after normal frataxin expression is restored (105).
Positive_regulation (restored) of Gene_expression (expression) of frataxin
8) Confidence 0.25 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.51 Pain Relevance 0

General Comments

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