INT315565

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.73
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC40A1) transmembrane transport (SLC40A1) cytoplasm (SLC40A1)
SLC40A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Porphyria 10 99.44 Very High Very High Very High
Stress 8 98.80 Very High Very High Very High
Iron Overload 48 97.48 Very High Very High Very High
Anaemia 36 96.04 Very High Very High Very High
Repression 4 91.92 High High
Ataxia 48 81.52 Quite High
Disease 54 81.12 Quite High
Muscle Disease 18 70.16 Quite High
Diabetes Mellitus 4 66.32 Quite High
Friedreich Ataxia 4 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
101), are activated, and they repress synthesis of proteins such as ferritin and ferroportin, which are encoded by transcripts that contain an IRP binding site in the 5?
Negative_regulation (repress) of Gene_expression (synthesis) of ferroportin
1) Confidence 0.25 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.63 Pain Relevance 0
The GLRX5 knockdown activates IRPs and thereby decreases the level of ALAS2 expression and interrupts heme biosynthesis, but activated IRPs cannot repress FPN1b expression, which is induced during the stress response to mitochondrial iron overload and worsens cytosolic iron deficiency in eythroid cells (Figure 3).
Negative_regulation (repress) of Gene_expression (expression) of FPN1b associated with stress, anaemia, porphyria and iron overload
2) Confidence 0.25 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.10 Pain Relevance 0

General Comments

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