INT315570

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TFRC) peptidase activity (TFRC) mitochondrion (TFRC)
aging (TFRC) extracellular region (TFRC) cytoplasmic membrane-bounded vesicle (TFRC)
TFRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron Overload 24 81.04 Quite High
Disease 27 50.00 Quite Low
Anaemia 18 31.32 Quite Low
Retina Disease 1 30.20 Quite Low
Intellectual Impairment 1 29.32 Quite Low
Syndrome 5 27.16 Quite Low
Lysosome Storage Disease 1 26.04 Quite Low
Ataxia 24 5.00 Very Low Very Low Very Low
Sideroblastic Anemia 15 5.00 Very Low Very Low Very Low
Muscle Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S cluster, IRP1 is activated to become an IRE-binding protein, which increases the rate of cellular iron uptake and decreases the rate of iron sequestration by stabilizing TfR1 mRNA and repressing ferritin synthesis.
Negative_regulation (decreases) of Positive_regulation (stabilizing) of TfR1
1) Confidence 0.19 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.08 Pain Relevance 0

General Comments

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