INT315572

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACO1) mitochondrion (ACO1) lyase activity (ACO1)
Golgi apparatus (ACO1) endoplasmic reticulum (ACO1) RNA binding (ACO1)
Anatomy Link Frequency
fibroblasts 1
ACO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron Overload 48 99.88 Very High Very High Very High
Muscle Disease 18 83.84 Quite High
Hyperplasia 2 77.08 Quite High
Neurologic Manifestations 2 71.32 Quite High
Ataxia 48 69.24 Quite High
Cirrhosis 2 68.52 Quite High
Diabetes Mellitus 4 67.92 Quite High
Sideroblastic Anemia 30 66.80 Quite High
Anaemia 36 58.40 Quite High
Disease 54 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S cluster, IRP1 is activated to become an IRE-binding protein, which increases the rate of cellular iron uptake and decreases the rate of iron sequestration by stabilizing TfR1 mRNA and repressing ferritin synthesis.
Positive_regulation (activated) of IRP1
1) Confidence 0.20 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.09 Pain Relevance 0
A recent rescue experiment of GLRX5 patient fibroblasts using a lentiviral vector that carries the wild-type GLRX5 gene sequence demonstrated that restored GLRX5 expression could improve cell growth, reverse mitochondrial iron overload, and increase aconitase activity (Figure 4) (32).
Positive_regulation (increase) of aconitase in fibroblasts associated with iron overload
2) Confidence 0.18 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.86 Pain Relevance 0

General Comments

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