INT315573

Context Info Confidence 0.24 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.74 Pain Relevance 0

cytosol (NFS1) mitochondrion (NFS1) small molecule metabolic process (NFS1) nucleus (NFS1) protein complex assembly (NFS1) cytoplasm (NFS1)

NFS1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 4 5.00 Glutamate 2 5.00

Disease Link Frequency Relevance Heat Iron Overload 48 70.92 Disease 54 63.44 Disease Progression 2 54.96 Anaemia 36 22.04 Ataxia 48 17.84 Sideroblastic Anemia 30 5.00 Muscle Disease 18 5.00 Porphyria 10 5.00 Syndrome 10 5.00 Erythropoietic Protoporphyria 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

S cluster biogenesis in eukaryotes was undermined by the discovery that isoforms of the cysteine desulfurase, ISCS, the scaffold, ISCU, and the alternative scaffold, NFU, not only were present in the cytosol but also were shown to be important for cytosolic Fe?

Negative_regulation (shown) of Gene_expression (isoforms) of cysteine desulfurase

1) Confidence 0.24 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.37 Pain Relevance 0

S cluster biogenesis in eukaryotes was undermined by the discovery that isoforms of the cysteine desulfurase, ISCS, the scaffold, ISCU, and the alternative scaffold, NFU, not only were present in the cytosol but also were shown to be important for cytosolic Fe?

Negative_regulation (shown) of Gene_expression (isoforms) of ISCS

2) Confidence 0.24 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.37 Pain Relevance 0

General Comments

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