INT315605

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB7) mitochondrion (ABCB7) ATPase activity (ABCB7)
transmembrane transport (ABCB7) cytoplasm (ABCB7)
ABCB7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematological Disease 3 99.46 Very High Very High Very High
Anaemia 54 97.48 Very High Very High Very High
Sideroblastic Anemia 45 96.04 Very High Very High Very High
Iron Overload 72 90.00 High High
Disease 81 82.52 Quite High
Targeted Disruption 6 80.40 Quite High
Disease Progression 3 74.04 Quite High
Ataxia 72 63.68 Quite High
Porphyria 15 45.68 Quite Low
Genomic Instability 6 12.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of function of the yeast counterpart of ABCB7, Atm1, resulted in a loss of activity of the cytosolic Fe?
ABCB7 Binding (counterpart) of
1) Confidence 0.33 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.61 Pain Relevance 0
Human ABCB7 has an additional role in heme synthesis and hematopoiesis as revealed by a putative interaction between ABCB7 and FECH which has been demonstrated in pull-down assays, and anemia caused by ABCB7 depletion (83,84).
ABCB7 Binding (interaction) of associated with hematological disease and anaemia
2) Confidence 0.33 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.70 Pain Relevance 0
S proteins such as Leu1p and that its homologue ABCB7 exported Fe?
ABCB7 Binding (its) of
3) Confidence 0.33 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.53 Pain Relevance 0

General Comments

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