INT315607

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.28
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GLRX5) nucleus (GLRX5)
Anatomy Link Frequency
fibroblasts 4
GLRX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 10 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Protein Deficiency 5 100.00 Very High Very High Very High
Iron Overload 120 98.00 Very High Very High Very High
Hyperplasia 5 80.84 Quite High
Muscle Disease 45 76.88 Quite High
Neurologic Manifestations 5 75.08 Quite High
Ataxia 120 73.00 Quite High
Cirrhosis 5 72.28 Quite High
Diabetes Mellitus 10 71.68 Quite High
Sideroblastic Anemia 75 70.56 Quite High
Anaemia 90 65.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent rescue experiment of GLRX5 patient fibroblasts using a lentiviral vector that carries the wild-type GLRX5 gene sequence demonstrated that restored GLRX5 expression could improve cell growth, reverse mitochondrial iron overload, and increase aconitase activity (Figure 4) (32).
Positive_regulation (restored) of Gene_expression (expression) of GLRX5 in fibroblasts associated with iron overload
1) Confidence 0.61 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.93 Pain Relevance 0
The GLRX5 protein deficiency results in a defect in Fe?
Positive_regulation (results) of Gene_expression (deficiency) of GLRX5 protein associated with protein deficiency
2) Confidence 0.44 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.41 Pain Relevance 0
GLRX5 may also function as a scaffold and may facilitate the transfer of Fe?
Positive_regulation (transfer) of Gene_expression (transfer) of GLRX5
3) Confidence 0.44 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0 Pain Relevance 0
A chaperone and cochaperone pair, known as HscA and HscB in bacteria or Ssq1 and Jac1 in yeast (20), respectively, along with a glutaredoxin, Grx5, are thought to facilitate the transfer of Fe?
Positive_regulation (transfer) of Gene_expression (transfer) of Grx5
4) Confidence 0.44 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0 Pain Relevance 0
A recent rescue experiment of GLRX5 patient fibroblasts using a lentiviral vector that carries the wild-type GLRX5 gene sequence demonstrated that restored GLRX5 expression could improve cell growth, reverse mitochondrial iron overload, and increase aconitase activity (Figure 4) (32).
Positive_regulation (restored) of Gene_expression (expression) of GLRX5 in fibroblasts associated with iron overload
5) Confidence 0.44 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.93 Pain Relevance 0

General Comments

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