INT315628

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.37
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FXN) mitochondrion (FXN) mitochondrion organization (FXN)
enzyme binding (FXN) cytoplasm (FXN)
FXN (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 12 100.00 Very High Very High Very High
Ataxia 70 99.84 Very High Very High Very High
Neurodegenerative Disease 7 92.48 High High
Disease 53 84.32 Quite High
Porphyria 5 81.76 Quite High
Hypertrophic Cardiomyopathy 3 74.64 Quite High
Diabetes Mellitus 4 72.08 Quite High
Thrombocytopenia 2 57.00 Quite High
Anaemia 18 49.88 Quite Low
Targeted Disruption 28 47.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Friedreich's ataxia (FA) is the most common form of autosomal recessive ataxia and it is caused by a decrease in the levels of frataxin, a mitochondrial protein encoded by the nuclear FRDA (FXN) gene [172].
Negative_regulation (decrease) of Gene_expression (levels) of frataxin associated with ataxia
1) Confidence 0.36 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.85 Pain Relevance 0
Since chromatin condensation around the GAA repeat is thought to be responsible, to some extent, for the low levels of frataxin mRNA expression in FA, histone deacetylase (HDAC) inhibitors have also been investigated with the same encouraging results [189, 190].
Negative_regulation (levels) of Gene_expression (expression) of frataxin mRNA associated with ataxia
2) Confidence 0.35 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.79 Pain Relevance 0
Under normal conditions in adult tissues, FXN is localized to the mitochondria, while under oxidative stress, a cytosolic FXN has been observed which may facilitate the regeneration of Fe?
Negative_regulation (stress) of Gene_expression (observed) of FXN associated with stress
3) Confidence 0.21 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.73 Pain Relevance 0

General Comments

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