INT315630

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2010
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 8
Total Number 27
Disease Relevance 20.05
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FXN) mitochondrion (FXN) mitochondrion organization (FXN)
enzyme binding (FXN) cytoplasm (FXN)
Anatomy Link Frequency
neurons 3
muscle 1
brain 1
cleavage 1
fibroblasts 1
FXN (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 20 50.16 Quite High
fibrosis 20 5.00 Very Low Very Low Very Low
Inflammation 20 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 274 99.86 Very High Very High Very High
Ataxia 628 99.84 Very High Very High Very High
Stress 108 99.72 Very High Very High Very High
Disease 449 99.52 Very High Very High Very High
Neurodegenerative Disease 67 99.16 Very High Very High Very High
Cold Sores 360 98.44 Very High Very High Very High
Factor Viii Deficiency 160 97.28 Very High Very High Very High
Porphyria 35 96.68 Very High Very High Very High
Iron Overload 168 95.84 Very High Very High Very High
Embryonic Lethality 60 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since chromatin condensation around the GAA repeat is thought to be responsible, to some extent, for the low levels of frataxin mRNA expression in FA, histone deacetylase (HDAC) inhibitors have also been investigated with the same encouraging results [189, 190].
Gene_expression (expression) of frataxin mRNA associated with ataxia
1) Confidence 0.64 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.79 Pain Relevance 0
There has been great interest in the possibility of boosting frataxin gene expression as a therapeutic approach and indeed, erythropoietin [187] has been shown to increase frataxin protein levels in cultured cells from FA patients.
Gene_expression (expression) of frataxin associated with ataxia
2) Confidence 0.64 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 1.22 Pain Relevance 0
Frataxin is expressed in all cell types, although cells from the nervous system, heart and muscle present the highest levels of the protein [180].
Gene_expression (expressed) of Frataxin in muscle
3) Confidence 0.64 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.75 Pain Relevance 0
This indicates that the FRDA-BAC contains all the regulatory elements needed for the FRDA gene to be expressed in a physiological fashion.
Gene_expression (expressed) of FRDA
4) Confidence 0.64 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.64 Pain Relevance 0
Interestingly, the expression of frataxin cDNA to “physiological” levels driven by a HSV-1 amplicon vector can rescue the neurodegeneration triggered by frataxin deficiency both in cultured neurons and in vivo [193].
Gene_expression (expression) of frataxin cDNA in neurons associated with cold sores
5) Confidence 0.64 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.57 Pain Relevance 0
Thus, it appears that the milder phenotype associated with the human disease is due to the residual frataxin expression observed in patients with the expansion mutations.
Gene_expression (expression) of frataxin associated with disease
6) Confidence 0.56 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.81 Pain Relevance 0
However, the nonphysiological overexpression of frataxin driven by these vectors has been shown to be cytopathological.
Gene_expression (overexpression) of frataxin
7) Confidence 0.56 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.63 Pain Relevance 0
However, it is not yet clear whether or not erythropoietin raises frataxin levels within affected neurons.
Gene_expression (levels) of frataxin in neurons
8) Confidence 0.56 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.88 Pain Relevance 0
However, it is not yet clear whether or not erythropoietin raises frataxin levels within affected neurons.
Neg (not) Spec (whether) Gene_expression (raises) of frataxin in neurons
9) Confidence 0.56 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.88 Pain Relevance 0
Thus, the entire FXN gene within a human YAC clone of 370?
Gene_expression (entire) of FXN gene
10) Confidence 0.56 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.59 Pain Relevance 0
Thus, physiologically regulated expression of frataxin gene seems to be important for the gene therapy to succeed in FA.
Gene_expression (expression) of frataxin associated with ataxia
11) Confidence 0.56 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.62 Pain Relevance 0
The resultant “transgenic-knockout” mice express comparatively little human-derived frataxin, and they exhibit a neurodegenerative and cardiac pathological phenotype similar to human disease sufferers, although significantly milder.
Neg (little) Gene_expression (express) of frataxin associated with targeted disruption, disease and neurodegenerative disease
12) Confidence 0.50 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 1.41 Pain Relevance 0
Friedreich's ataxia (FA) is the most common form of autosomal recessive ataxia and it is caused by a decrease in the levels of frataxin, a mitochondrial protein encoded by the nuclear FRDA (FXN) gene [172].
Gene_expression (levels) of frataxin associated with ataxia
13) Confidence 0.50 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.85 Pain Relevance 0
Interestingly, the episome carrying the frataxin gene (deficient in Friedreich's ataxia) has been demonstrated to rescue the susceptibility to oxidative stress which is typical of fibroblasts from Friedreich's ataxia patients.
Gene_expression (deficient) of frataxin in fibroblasts associated with stress and ataxia
14) Confidence 0.50 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2938438 Disease Relevance 0.58 Pain Relevance 0
Once FRDA expression from the iBAC has been demonstrated, the iBAC might be used for in vivo delivery of the FRDA gene to FA-affected regions since delivery of HSV-1 amplicons to determined brain regions has already been shown [127].
Gene_expression (expression) of FRDA in brain associated with cold sores and ataxia
15) Confidence 0.50 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.92 Pain Relevance 0.05
After 8 weeks of treatment, only two patients experienced a net increment in frataxin levels in peripheral blood lymphocytes, patients who also showed a reduction in markers of oxidative stress.
Gene_expression (levels) of frataxin in lymphocytes associated with stress
16) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.95 Pain Relevance 0
As mentioned above, it seems that optimal frataxin levels are required for correct cell function, since both deficiency and massive overexpression are associated with cell pathology.
Gene_expression (overexpression) of frataxin
17) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.68 Pain Relevance 0
Human FXN protein is synthesized as a 210-amino acid precursor protein, but multiple smaller intermediate forms are found which do not conform to the sizes expected after traditional mitochondrial import, cleavage, and processing.
Gene_expression (synthesized) of FXN protein in cleavage
18) Confidence 0.45 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.61 Pain Relevance 0
Friedreich's ataxia (FA) is the most common form of autosomal recessive ataxia and it is caused by a decrease in the levels of frataxin, a mitochondrial protein encoded by the nuclear FRDA (FXN) gene [172].
Gene_expression (levels) of FXN associated with ataxia
19) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.87 Pain Relevance 0
Moreover, in a yeast model of frataxin deficiency, iron is mobilized from the iron overloaded mitochondria within minutes after normal frataxin expression is restored (105).
Gene_expression (expression) of frataxin
20) Confidence 0.39 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.51 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox