INT315635

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 5.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FXN) mitochondrion (FXN) mitochondrion organization (FXN)
enzyme binding (FXN) cytoplasm (FXN)
FXN (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 5 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 92 99.84 Very High Very High Very High
Targeted Disruption 67 99.16 Very High Very High Very High
Neurodegenerative Disease 16 99.16 Very High Very High Very High
Ataxia 139 98.44 Very High Very High Very High
Porphyria 5 94.80 High High
Embryonic Lethality 15 89.24 High High
Cold Sores 90 86.96 High High
Stress 24 83.84 Quite High
Dysarthria 1 62.32 Quite High
Hypertrophic Cardiomyopathy 6 54.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that the FRDA-BAC contains all the regulatory elements needed for the FRDA gene to be expressed in a physiological fashion.
Positive_regulation (needed) of FRDA
1) Confidence 0.41 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.64 Pain Relevance 0
There has been great interest in the possibility of boosting frataxin gene expression as a therapeutic approach and indeed, erythropoietin [187] has been shown to increase frataxin protein levels in cultured cells from FA patients.
Positive_regulation (increase) of frataxin associated with ataxia
2) Confidence 0.41 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 1.07 Pain Relevance 0
The resultant “transgenic-knockout” mice express comparatively little human-derived frataxin, and they exhibit a neurodegenerative and cardiac pathological phenotype similar to human disease sufferers, although significantly milder.
Positive_regulation (derived) of frataxin associated with targeted disruption, disease and neurodegenerative disease
3) Confidence 0.41 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 1.39 Pain Relevance 0
FA is a good candidate for treatment with gene therapy as it is a monogenic disease and an increases in frataxin level could substantially improved the symptoms given that healthy carriers may have around 40%–50% of normal frataxin levels [191].
Positive_regulation (increases) of frataxin associated with ataxia and disease
4) Confidence 0.36 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.76 Pain Relevance 0
In a pilot clinical trial, 12 patients were treated with human recombinant erythropoietin (rHeEPO) to establish whether it could produce an increment in frataxin levels [188].
Positive_regulation (increment) of frataxin
5) Confidence 0.36 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.91 Pain Relevance 0
However, it is widely believed that the main role of FXN is to supply iron in a bioavailable form for mitochondrial Fe?
Positive_regulation (role) of FXN
6) Confidence 0.29 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.99 Pain Relevance 0

General Comments

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