INT315798

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.91
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rit1) plasma membrane (Rit1) GTPase activity (Rit1)
Anatomy Link Frequency
vasculature 1
vessels 1
Rit1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 77 79.36 Quite High
positron emission tomography 32 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 249 99.84 Very High Very High Very High
Recurrence 14 96.52 Very High Very High Very High
Coronary Artery Disease 62 94.72 High High
Disease 41 91.40 High High
Lymphatic System Cancer 68 86.88 High High
Infection 1 83.36 Quite High
Toxicity 31 82.00 Quite High
Follicular Lymphoma 13 76.96 Quite High
Hypersensitivity 5 74.40 Quite High
Aging 1 66.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overall remission rate seen in our patients was 59.4% translating into a median PFS of 18 months (overall) [21 months for patients receiving RIT for primary treatment, 8.3 and 6.7 months for patients receiving RIT for locoregional relapse/re-irradiation] and a locoregional PFS of 15 mo (overall) [not reached for primary treatment/treatment for local relapse; 10 mo for re-irradiation] respectively.
RIT Binding (receiving) of associated with recurrence
1) Confidence 0.25 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC3002347 Disease Relevance 0.68 Pain Relevance 0
RIT targeted to the tumor vessels improved median survival and tumor regression
RIT Binding (targeted) of in vessels associated with cancer
2) Confidence 0.19 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.98 Pain Relevance 0.04
RIT study to target and irradiate the tumor vasculature (survival and tumor regression)
RIT Binding (target) of in vasculature associated with cancer
3) Confidence 0.19 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 1.35 Pain Relevance 0
Given some of the obvious similarities in mechanism of action between immunotherapy and RIT, one wonders whether patients who are no longer susceptible to immunotherapy may still respond to RIT.
RIT Binding (respond) of
4) Confidence 0.12 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.90 Pain Relevance 0

General Comments

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