INT31580

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 3.48
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp11a1)
Anatomy Link Frequency
hepatocytes 1
adrenal glands 1
DRG 1
Cyp11a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 10 99.98 Very High Very High Very High
antagonist 23 99.34 Very High Very High Very High
Paracetamol 10 98.28 Very High Very High Very High
Central nervous system 5 96.88 Very High Very High Very High
tricyclic antidepressant 8 96.68 Very High Very High Very High
lidocaine 6 96.24 Very High Very High Very High
Spinal cord 3 96.24 Very High Very High Very High
monoamine 1 95.04 Very High Very High Very High
cva 12 91.92 High High
Somatosensory cortex 1 91.28 High High
Disease Link Frequency Relevance Heat
Reprotox - General 1 41 96.96 Very High Very High Very High
Hepatotoxicity 2 96.72 Very High Very High Very High
Vomiting 87 94.32 High High
Thrombosis Related Under Development 2 91.92 High High
Endometriosis (extended) 10 90.80 High High
Breast Cancer 4 90.48 High High
Thrombocytopenia 2 89.56 High High
Nociception 3 89.28 High High
Disease 8 89.16 High High
Depression 2 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that S-petasin inhibits the production of corticosterone from rat ZFR cells in part through decreasing the activities of adenylyl cyclase, P450scc and 11beta-hydroxylase.
Negative_regulation (decreasing) of P450scc
1) Confidence 0.57 Published 2002 Journal Chin J Physiol Section Abstract Doc Link 12817704 Disease Relevance 0 Pain Relevance 0
Incubation of DRG, SSN or SC tissue homogenates with [3H]cholesterol yielded the formation of radioactive metabolites including [3H]pregnenolone of which the synthesis was reduced in presence of aminogluthetimide, a P450scc inhibitor.
Negative_regulation (inhibitor) of P450scc in DRG associated with spinal cord
2) Confidence 0.43 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12911631 Disease Relevance 0.33 Pain Relevance 0.53
In summary, the actions of S-petasin mediate the inhibition of cAMP formation, decrease the activities of key enzymes P450scc and 11beta-hydroxylase, and reduce mRNA of steroidogenic acute regulatory protein and expression of steroidogenic acute regulatory protein.
Negative_regulation (decrease) of P450scc
3) Confidence 0.40 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063152 Disease Relevance 0 Pain Relevance 0.06
Some of the fluoroquinolones (norfloxacin, ciprofloxacin, and ofloxacin) can inhibit the cytochrome P-450 enzyme system and thereby cause increased serum concentrations of drugs like theophylline and caffeine.
Negative_regulation (inhibit) of cytochrome P-450 enzyme
4) Confidence 0.36 Published 1993 Journal Clin. Infect. Dis. Section Abstract Doc Link 8399914 Disease Relevance 0.30 Pain Relevance 0.15
The sequential metabolism of 7DHC to 7DHP in rat and pig adrenal glands, and to 17(OH)7DHP in pig, was inhibited by DL-aminoglutethimide (AGT, an inhibitor of P450scc) and stimulated by forscolin (Fig. 5A–C).
Negative_regulation (inhibitor) of P450scc in adrenal glands
5) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0 Pain Relevance 0
The most common interactions involve changes in the pharmacokinetics or pharmacodynamics of one drug caused by induction or inhibition of the cytochrome P450 enzyme system by another drug.
Negative_regulation (inhibition) of cytochrome P450 enzyme
6) Confidence 0.14 Published 1997 Journal J Clin Anesth Section Abstract Doc Link 9278848 Disease Relevance 0.09 Pain Relevance 0.25
Knowledge of kinetic characteristics is important for designing dosage regimens and avoiding potentially serious drug-drug interactions that are mediated through inhibition of specific hepatic cytochrome P450 enzyme pathways.
Negative_regulation (inhibition) of cytochrome P450 enzyme
7) Confidence 0.13 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 7992822 Disease Relevance 0.08 Pain Relevance 0.49
Each of the SSRIs inhibits at least one cytochrome P450 enzyme, and all of the SSRIs increase serum concentrations of concomitantly administered TCAs.
Negative_regulation (inhibits) of cytochrome P450 enzyme associated with tricyclic antidepressant and ssri
8) Confidence 0.13 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 7992822 Disease Relevance 0.08 Pain Relevance 0.44
A separate group of rats (n = 6) received cimetidine (an inhibitor of the CYP450 enzyme system) at a dose of 80 mg/kg daily for 3 days.
Negative_regulation (inhibitor) of CYP450 enzyme
9) Confidence 0.13 Published 1999 Journal Shock Section Abstract Doc Link 10588516 Disease Relevance 0.15 Pain Relevance 0.39
The interaction that occurs with theophylline and warfarin when the cytochrome P-450 enzyme system is inhibited by cimetidine and ranitidine requires monitoring.
Negative_regulation (inhibited) of cytochrome P-450 enzyme
10) Confidence 0.10 Published 1987 Journal Pharmacotherapy Section Abstract Doc Link 2895455 Disease Relevance 0.30 Pain Relevance 0.31
Because the H2-receptor antagonists elevate gastric pH, bind to and inhibit the hepatic cytochrome P-450 enzyme system, and undergo renal tubular secretion, competition with other drugs sharing these pathways has resulted in a number of drug interactions, most of which are not clinically significant.
Negative_regulation (inhibit) of cytochrome P-450 enzyme associated with antagonist
11) Confidence 0.07 Published 1987 Journal Pharmacotherapy Section Abstract Doc Link 2895455 Disease Relevance 0.35 Pain Relevance 0.35
Studies in isolated hamster hepatocytes indicated that cysteamine competitively inhibited the cytochrome P-450 enzyme system as represented by formation of the acetaminophen-glutathione conjugate.
Negative_regulation (inhibited) of cytochrome P-450 enzyme in hepatocytes associated with paracetamol
12) Confidence 0.05 Published 1986 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 3952741 Disease Relevance 0.17 Pain Relevance 0.56
Because aprepitant is a moderate inhibitor of the cytochrome P450 enzyme (CYP3A4), concern initially arose about whether aprepitant might affect the clearance of taxanes and vinca alkaloids that are metabolized by that enzyme.
Negative_regulation (inhibitor) of cytochrome P450 enzyme
13) Confidence 0.01 Published 2008 Journal Current Oncology Section Body Doc Link PMC2216421 Disease Relevance 0.65 Pain Relevance 0.03
Exemestane is an irreversible, highly specific, inhibitor of the cytochrome p450 enzyme, aromatase.
Negative_regulation (inhibitor) of cytochrome p450 enzyme
14) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697518 Disease Relevance 0.98 Pain Relevance 0.05

General Comments

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