INT31582

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Context Info
Confidence 0.66
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 103
Total Number 103
Disease Relevance 118.95
Pain Relevance 6.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 11
Heart 2
liver 2
hepatocyte 2
aorta 1
Hdl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 902 100.00 Very High Very High Very High
Bile 317 99.80 Very High Very High Very High
psoriasis 189 99.68 Very High Very High Very High
agonist 1251 99.54 Very High Very High Very High
Somatostatin 9 97.48 Very High Very High Very High
Angina 208 96.36 Very High Very High Very High
aspirin 299 96.00 Very High Very High Very High
antagonist 189 95.56 Very High Very High Very High
Inflammatory response 29 94.70 High High
chemokine 21 94.40 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 17318 100.00 Very High Very High Very High
Atherosclerosis 3200 100.00 Very High Very High Very High
INFLAMMATION 951 100.00 Very High Very High Very High
Cardiovascular Disease 533 100.00 Very High Very High Very High
Death 528 100.00 Very High Very High Very High
Targeted Disruption 400 100.00 Very High Very High Very High
Insulin Resistance 258 100.00 Very High Very High Very High
Hypertriglyceridemia 204 100.00 Very High Very High Very High
Coronary Heart Disease 3332 99.76 Very High Very High Very High
Psoriasis 318 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, to evaluate the association between low levels of high-density lipoprotein cholesterol (HDL-C) and elevated ratio of serum cholesterol to HDL-C with these outcomes.
Gene_expression (levels) of high-density lipoprotein cholesterol associated with disorder of lipid metabolism
1) Confidence 0.66 Published 1994 Journal JAMA Section Abstract Doc Link 7772105 Disease Relevance 0.56 Pain Relevance 0.10
Correlations of high-density lipoprotein cholesterol (HDL-C), expressed in either absolute or relative terms, with a series of coronary risk factors and other variables were examined in the Israeli Ischemic Heart Disease Study sample.
Gene_expression (expressed) of high-density lipoprotein cholesterol in Heart associated with coronary artery disease and disorder of lipid metabolism
2) Confidence 0.66 Published 1986 Journal Prev Med Section Abstract Doc Link 3797389 Disease Relevance 1.15 Pain Relevance 0.05
When ABCA-1 is absent or dysfunctional, the apo A-1 gets catabolized too quickly leading to lower levels of apo A-1, and thus lower levels of HDL.
Gene_expression (levels) of HDL associated with disorder of lipid metabolism
3) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.98 Pain Relevance 0.04
Thus, therapies to raise the HDL hold promise for additional cardiac risk reduction.
Gene_expression (raise) of HDL associated with disorder of lipid metabolism
4) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2988622 Disease Relevance 1.04 Pain Relevance 0.05
Attempts to raise HDL are becoming increasingly frequent in the literature and most agree that raising HDL should be one of the goals in the management of atherogenic dyslipidemias for CHD risk reduction.
Gene_expression (raising) of HDL associated with coronary heart disease and disorder of lipid metabolism
5) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.28 Pain Relevance 0.12
Aggressive statin monotherapy for raising HDL
Gene_expression (raising) of HDL associated with disorder of lipid metabolism
6) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.65 Pain Relevance 0.04
Principles and goals of HDL therapy
Gene_expression (therapy) of HDL associated with disorder of lipid metabolism
7) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.90 Pain Relevance 0
The 2004 update to the NCEP ATP III guidelines has the following additional recommendation: ‘For those high-risk patients who have elevated triglycerides or low HDL levels, addition of a fibrate or nicotinic acid to the routine LDL-lowering therapy can be considered’.23


Gene_expression (levels) of HDL associated with hypertriglyceridemia and disorder of lipid metabolism
8) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.41 Pain Relevance 0.03
35 mg/dL) showed a significantly higher rate of major cardiovascular events than those with higher HDL levels (>42.5 mg/dL).10 Thus, statin treatment alone does not appear to be good enough to eliminate the risk associated with low HDL.
Gene_expression (levels) of HDL associated with disorder of lipid metabolism
9) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.51 Pain Relevance 0
Attempts to raise HDL are becoming increasingly frequent in the literature and most agree that raising HDL should be one of the goals in the management of atherogenic dyslipidemias for CHD risk reduction.
Gene_expression (raise) of HDL associated with coronary heart disease and disorder of lipid metabolism
10) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.34 Pain Relevance 0.05
The ABCA-1 receptor molecule is responsible for lipidating only newly secreted apoA-1, while the ABCG-1 and SR-B1 receptors can directly lipidate HDL molecule.
Gene_expression (lipidate) of HDL molecule associated with disorder of lipid metabolism
11) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.76 Pain Relevance 0
The majority of the HDL exists as HDL-3.
Gene_expression (majority) of HDL associated with disorder of lipid metabolism
12) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.15 Pain Relevance 0
A study reported by Dodani et al attempted to identify apo A-1 polymorphisms, the main protein component of HDL and explore its association with low HDL levels in South Asians.20 The study was conducted on 30 South Asians.
Gene_expression (levels) of HDL associated with disorder of lipid metabolism
13) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.31 Pain Relevance 0
Despite the concern over niacin use and potential for the interference with glucose control, it has been shown that niacin in moderate doses, ie, 750 to 2000 mg daily, significantly improves LDL, HDL, and TG levels and causes only minor variation in glucose level that can be generally corrected through therapeutic adjustment.


Gene_expression (improves) of HDL associated with disorder of lipid metabolism
14) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.29 Pain Relevance 0
Despite significant favorable improvements in LDL and HDL in the torcetrapib/atorvastatin group, change in maximum CIMT was not significantly different in the torcetrapib/atorvastatin group (x = 0.025 mm/year) compared with the atorvastatin monotherapy group (x = 0.030 mm/year, P = 0.46).31
Gene_expression (improvements) of HDL associated with disorder of lipid metabolism
15) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.45 Pain Relevance 0.03
Similarly, the Treating to New Targets (TNT) study (subgroup analysis of 2661 subjects) showed that patients in the aggressively treated group who had achieved the lowest LDL levels of about 58 mg/dL still exhibited a significant risk of major cardiovascular events over the 5 year follow up if their HDL-C was low.12 The subjects in the highest HDL quintile (HDL ?
Gene_expression (quintile) of HDL associated with disorder of lipid metabolism
16) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.78 Pain Relevance 0
Suppression of CETP activity has recently been the focus of development of new therapeutic agents for raising plasma levels of HDL.15

Additional beneficial properties of HDL

Gene_expression (properties) of HDL in plasma associated with disorder of lipid metabolism
17) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.10 Pain Relevance 0.09
When quantitative coronary angiography (QCA) was used for the same patients, the mean percent diameter stenosis was reduced from 37.3% to 36.0% after 24 months of rosuvastatin 40 mg therapy (P < 0.001).46

Combination therapies for raising HDL

Gene_expression (raising) of HDL associated with pathologic constriction and disorder of lipid metabolism
18) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.51 Pain Relevance 0
Despite the concern over niacin use and potential for the interference with glucose control, it has been shown that niacin in moderate doses, ie, 750 to 2000 mg daily, significantly improves LDL, HDL, and TG levels and causes only minor variation in glucose level that can be generally corrected through therapeutic adjustment.


Gene_expression (levels) of HDL associated with disorder of lipid metabolism
19) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.29 Pain Relevance 0
The most common form of dyslipidemia in the diabetics includes co-existence of high levels of TG and low serum levels of HDL.24 ADA 2008 guidelines recommend initiation of statin therapy to lifestyle therapy irrespective of the lipid levels for all diabetics who have either manifest CHD or ?
Gene_expression (guidelines) of HDL associated with diabetes mellitus, coronary heart disease and disorder of lipid metabolism
20) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.55 Pain Relevance 0

General Comments

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