INT315831

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
hepatocyte 2
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 10.52 Low Low
aspirin 7 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 33 89.88 High High
Mouth Cancer 1 89.16 High High
Metastasis 9 64.40 Quite High
Adenocarcinoma 5 57.24 Quite High
Non-small-cell Lung Cancer 40 57.20 Quite High
Colon Cancer 4 51.20 Quite High
Apoptosis 6 32.48 Quite Low
Transitional Cell Carcinoma 1 19.16 Low Low
Acne 1 18.48 Low Low
Exanthema 6 17.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cancer cells expressing EGFR and ErbB2 are nonresponsive to inhibitors targeting one of these two proteins.63 Similarly, overexpression of ErbB3 also confers resistance to EGFR inhibitors.64 Expression of hepatocyte growth factor and c-Met dependent signaling is also an alternative pathway for signaling conferring resistance (seen in approximately 20% of patients with acquired resistance to TKIs).65 Finally, interactions between EGFR and the insulin growth factor receptor (IGF-1R) can provide resistance to agents targeting EGFR.66
Positive_regulation (agents) of Localization (targeting) of EGFR in hepatocyte associated with cancer
1) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.38 Pain Relevance 0
-catenin is a direct target of EGFR requires further determination.

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Positive_regulation (requires) of Localization (target) of EGFR
2) Confidence 0.14 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.23 Pain Relevance 0

General Comments

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