INT315832

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BTC) extracellular region (BTC) plasma membrane (BTC)
BTC (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 38.72 Quite Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 20 94.32 High High
Apoptosis 3 92.20 High High
Non-small-cell Lung Cancer 40 67.80 Quite High
Squamous Cell Neoplasms 1 37.32 Quite Low
Large Cell Carcinoma 2 32.80 Quite Low
Adenocarcinoma 4 31.80 Quite Low
Disease 21 5.00 Very Low Very Low Very Low
Lung Cancer 12 5.00 Very Low Very Low Very Low
Toxicity 11 5.00 Very Low Very Low Very Low
Disease Progression 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF and transforming growth factor (TGF) alpha appear to be key ligands, but others, like epiregulin, betacellulin, epigen, and amphiregulin, have been shown to be relevant predictors of response and resistance.29,30 A series of downstream signals lead to tumor proliferation, angiogenesis, and inhibition of apoptosis by the Ras-Raf-Mitogen activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3)-Akt pathways.31,32 Interaction between EGFR expression and STAT 3 (signal transducers and activators of transcription 3) has also been shown to be important in gene transcription.33–35
Gene_expression (others) of betacellulin associated with cancer and apoptosis
1) Confidence 0.10 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.43 Pain Relevance 0

General Comments

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