INT315844

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.59
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Btk) cytosol (Btk) plasma membrane (Btk)
nucleus (Btk) kinase activity (Btk) cytoplasm (Btk)
Btk (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 8 51.60 Quite High
Eae 9 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intellectual Impairment 2 86.80 High High
Hyperplasia 4 84.96 Quite High
Epilepsy 1 82.96 Quite High
Language Development Disorders 1 79.08 Quite High
Solid Tumor 1 72.92 Quite High
Myeloid Leukemia 85 63.92 Quite High
Cancer 6 50.24 Quite High
Leukemia 15 50.00 Quite Low
Targeted Disruption 9 50.00 Quite Low
Blast Crisis 4 15.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and Kit at nanomolar to sub-nanomolar concentrations (Table 1).11 Recently, dasatinib was also shown to bind to other tyrosine and serine/threonine kinases, such as the TEC family kinases, BTK and TEC, the mitogen-activated protein kinases, the receptor tyrosine kinase, discoidin domain receptor 1 and the ephrin receptors.12
BTK Binding (bind) of
1) Confidence 0.16 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.34 Pain Relevance 0
CrT deficiency is a relatively newly recognized disorder and is not routinely screened which makes estimates of the prevalence difficult to determine.
deficiency Binding (recognized) of
2) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020968 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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