INT315848

Context Info Confidence 0.20 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.61 Pain Relevance 0.05

mitochondrion (Abl1) DNA binding (Abl1) cytoplasm (Abl1) cytosol (Abl1) nucleolus (Abl1) cell adhesion (Abl1)

Abl1 (Mus musculus)

Pain Link Frequency Relevance Heat Potency 4 95.44 rheumatoid arthritis 1 30.80 cytokine 1 15.92 Central nervous system 7 5.00 corticosteroid 2 5.00 headache 2 5.00 imagery 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Fever 3 83.64 Colitis 1 82.84 Cytomegalovirus Infection 1 81.96 Pneumonia 1 81.76 Pleural Effusion 18 81.24 Lymphocytosis 2 77.08 Systemic Lupus Erythematosus 1 54.12 Leukemia 15 50.00 Pressure And Volume Under Development 5 49.80 Arthralgia 1 48.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These include upregulation of the ABCB1 or ABCG2 drug efflux pumps,58,63,64 downregulation of human organic cation transporter 1 (hOCT1) drug influx transporters,65,66 overexpression of Lyn, a Src-family kinase,67 and other Bcr-Abl-independent mechanisms.

Positive_regulation (upregulation) of Negative_regulation (downregulation) of Abl

1) Confidence 0.20 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.61 Pain Relevance 0.05

General Comments

This test has worked.