INT315882

Context Info Confidence 0.44 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.39 Pain Relevance 0

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN) plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)

PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat abdominal pain 2 5.00 pruritus 2 5.00 positron emission tomography 2 5.00 fibrosis 1 5.00 Pain 1 5.00 local anesthetic 1 5.00 backache 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Cancer 131 99.48 Apoptosis 5 95.44 Hyperplasia 1 92.20 Colorectal Cancer 37 82.08 Microsatellite Instability 2 55.40 Adenocarcinoma 9 50.00 Lung Cancer 10 38.64 Thyroid Neoplasm 1 37.68 Toxicity 19 28.36 Congenital Anomalies 1 23.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PTEN (the lipid phosphatase and tensin homolog) is a key tumor suppressor that normally regulates the activation of PI3K.66 The loss of PTEN and mutations in PI3K have been proposed to predict resistance to EGFR inhibitors, however, this is preliminary and no definite conclusions can be derived.64 Conclusions

Regulation (regulates) of Negative_regulation (loss) of PTEN associated with cancer

1) Confidence 0.44 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886332 Disease Relevance 0.54 Pain Relevance 0

These changes mitigate the effect of PTEN loss on the PI3K/AKT pathway and suggest that the loss of PTEN serves primarily to further activate the RET pathway to drive tumor growth.

Regulation (effect) of Negative_regulation (loss) of PTEN associated with cancer

2) Confidence 0.42 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.86 Pain Relevance 0

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