INT315883

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK1) cytoskeleton (JAK1) nucleus (JAK1)
cytoplasm (JAK1)
JAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
pruritus 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 70.88 Quite High
Colorectal Cancer 37 70.24 Quite High
Malignant Neoplastic Disease 3 68.72 Quite High
Metastasis 2 54.88 Quite High
Cancer 26 48.88 Quite Low
Adenocarcinoma 1 37.12 Quite Low
Apoptosis 3 13.48 Low Low
Toxicity 19 5.00 Very Low Very Low Very Low
Exanthema 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This phosphorylation results in the activation of several intracellular second-messenger signal transduction pathways, such as the Janus kinase-Signal transducer an activator of transcription signaling, the phosphatidylinositol-3-kinase and the protein-serine/threonine kinase Akt signal, and the Ras-Raf-MAP-kinase signal, which further activates the mitogen-activated phosphorylation protein kinases.
Positive_regulation (results) of Positive_regulation (activation) of Janus kinase-Signal
1) Confidence 0.01 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886332 Disease Relevance 0.38 Pain Relevance 0

General Comments

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