INT315886

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
pruritus 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 26 99.48 Very High Very High Very High
Apoptosis 3 95.44 Very High Very High Very High
Colorectal Cancer 37 80.48 Quite High
Microsatellite Instability 2 55.40 Quite High
Toxicity 19 28.36 Quite Low
Exanthema 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Diarrhoea 8 5.00 Very Low Very Low Very Low
Disease Progression 7 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTEN (the lipid phosphatase and tensin homolog) is a key tumor suppressor that normally regulates the activation of PI3K.66 The loss of PTEN and mutations in PI3K have been proposed to predict resistance to EGFR inhibitors, however, this is preliminary and no definite conclusions can be derived.64

Conclusions

Regulation (regulates) of Positive_regulation (activation) of PI3K associated with cancer
1) Confidence 0.10 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886332 Disease Relevance 0.53 Pain Relevance 0

General Comments

This test has worked.

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