INT315907

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ALB, Sparc) extracellular space (ALB, Sparc) extracellular region (ALB, Sparc)
transport (ALB) small molecule metabolic process (ALB) intracellular (Sparc)
ALB (Homo sapiens)
Sparc (Mus musculus)
Pain Link Frequency Relevance Heat
Antihistamine 12 5.00 Very Low Very Low Very Low
peripheral neuropathy 9 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
induced neuropathy 6 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Parenteral administration 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Demyelination 3 5.00 Very Low Very Low Very Low
Root ganglion neuron 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 90 99.68 Very High Very High Very High
Breast Cancer 81 96.52 Very High Very High Very High
Aggression 3 79.20 Quite High
Neutropenia 69 5.00 Very Low Very Low Very Low
Toxicity 60 5.00 Very Low Very Low Very Low
Neuropathic Pain 51 5.00 Very Low Very Low Very Low
Advanced Or Metastatic Breast Cancer 42 5.00 Very Low Very Low Very Low
Disease 42 5.00 Very Low Very Low Very Low
Fever 21 5.00 Very Low Very Low Very Low
Hypersensitivity 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, the high affinity of SPARC for albumin is an albumin-cytotoxic uptake agent which serves to concentrate SPARC in the tumor.
albumin Binding (affinity) of SPARC associated with cancer
1) Confidence 0.06 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 1.24 Pain Relevance 0
SPARC is overexpressed in breast cancer and has been implicated in tumor progression and angiogenesis.31 Nab-paclitaxel enhances tumor targeting through gp60 and caveolae-mediated endothelial transcytosis and the association with the albumin-binding protein SPARC in the tumor microenvironment.
albumin Binding (association) of SPARC associated with cancer and breast cancer
2) Confidence 0.05 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 1.19 Pain Relevance 0
As a result, the high affinity of SPARC for albumin is an albumin-cytotoxic uptake agent which serves to concentrate SPARC in the tumor.
albumin-cytotoxic Binding (affinity) of SPARC associated with cancer
3) Confidence 0.05 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 1.24 Pain Relevance 0

General Comments

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