INT315967

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.86
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Msc) DNA binding (Msc)
Msc (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 17 95.48 Very High Very High Very High
Potency 1 48.20 Quite Low
fibrosis 10 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
interstitial cystitis 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 124 99.84 Very High Very High Very High
Necrosis 10 86.72 High High
Cancer 55 85.84 High High
Apoptosis 19 79.76 Quite High
Obesity 1 79.24 Quite High
Severe Combined Immunodeficiency 18 50.00 Quite Low
Sarcoma 2 31.04 Quite Low
Malignant Neoplastic Disease 4 26.76 Quite Low
Hematologic Neoplasms 4 12.36 Low Low
Fibrosis 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results derived from these experiments tend to exclude a significant direct cytotoxic effect of MSC on lymphoma cells, since MSC moderately inhibited the viability of BJAB but did not exhibit any appreciable effect on SKW6.4 cell survival/growth.
Negative_regulation (effect) of MSC associated with lymphatic system cancer
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.85 Pain Relevance 0.07
In order to ascertain whether the anti-lymphoma activity of MSC observed in vivo was due to a direct inhibitory effect of MSC on lymphoma cells, we have tested whether MSC could modulate the survival/growth of BJAB and SKW6.4 cells in an in vitro co-culture system.
Negative_regulation (effect) of MSC associated with lymphatic system cancer
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.93 Pain Relevance 0.07
Even a small number of MSC can multiply into millions of cells under the right culture conditions.
Negative_regulation (number) of MSC
3) Confidence 0.02 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3022195 Disease Relevance 0.08 Pain Relevance 0

General Comments

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