INT315979

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.96
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Rhd) biological_process (Rhd)
Anatomy Link Frequency
blood 1
immune cells 1
hematopoietic progenitor cells 1
paw 1
lymphocytes 1
Rhd (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 19 57.52 Quite High
Inflammation 22 50.00 Quite Low
Thermal hyperalgesia 13 50.00 Quite Low
antinociception 5 50.00 Quite Low
cINOD 12 47.92 Quite Low
cytokine 26 44.12 Quite Low
Hyperalgesia 11 34.40 Quite Low
Pain 10 25.04 Quite Low
Arthritis 10 23.28 Low Low
rheumatoid arthritis 8 16.64 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 45 91.68 High High
Hematological Disease 50 89.36 High High
Osteoporosis 20 74.36 Quite High
Death 55 71.56 Quite High
Radiation Sickness 50 61.72 Quite High
Infection 35 52.00 Quite High
Hyperalgesia 24 50.00 Quite Low
INFLAMMATION 22 50.00 Quite Low
Arthritis 16 45.76 Quite Low
Nociception 13 44.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coadministration of minocycline 50 mg/kg plus indomethacin 1 mg/kg to mice with LPS-induced monoarthritis significantly increased the RH/LH paw pressure or print area at 1 hour post treatment by 34.5 ± 12.3% and 85.8 ± 23.8% respectively, compared to drug vehicle treated monoarthritic animals which had -0.6 ± 10.1% and -5.4 ± 23.7% change at 1 hour post treatment for RH/LH paw pressure and print area respectively (Figure 4C,D).
Positive_regulation (increased) of RH in paw
1) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009629 Disease Relevance 0 Pain Relevance 0.03
Since the number of hematopoietic stem cells is increased in the rhGH-treated mice (Table 1), it was expected that immune recovery is also accelerated in these animals as demonstrated in Fig. 3. rhGH can also stimulate the expansion of mature immune cells directly [41].
Positive_regulation (increased) of rhGH in immune cells
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886847 Disease Relevance 0.42 Pain Relevance 0
Measurement of CFCs in the bone marrow at day +14 (Table 1) conclusively demonstrate the contents of all lineages of hematopoietic progenitor cells are increased after rhGH treatment.
Positive_regulation (increased) of rhGH in hematopoietic progenitor cells
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886847 Disease Relevance 0.14 Pain Relevance 0
Even though there were clear treads toward increased neutrophils and lymphocytes in the rhGH treated cynomolgus monkeys (Fig. 7), the differences were not significant, probably due to small sample sizes.
Positive_regulation (increased) of rhGH in neutrophils
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886847 Disease Relevance 0.06 Pain Relevance 0
After treated with rhGH, IGF-1 levels were significantly increased compared with the saline control group, demonstrating that the treatment with rhGH does increase the blood level of IGF-1.


Positive_regulation (increased) of rhGH in blood
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886847 Disease Relevance 0.27 Pain Relevance 0
Even though there were clear treads toward increased neutrophils and lymphocytes in the rhGH treated cynomolgus monkeys (Fig. 7), the differences were not significant, probably due to small sample sizes.
Positive_regulation (increased) of rhGH in lymphocytes
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886847 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox