INT31598

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 41
Total Number 42
Disease Relevance 6.44
Pain Relevance 6.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mgst1) endoplasmic reticulum (Mgst1) nucleus (Mgst1)
Anatomy Link Frequency
hepatocyte 2
liver 2
4T1 1
brain 1
lung 1
Mgst1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 86 99.08 Very High Very High Very High
Bile 53 95.36 Very High Very High Very High
depression 19 94.60 High High
ischemia 16 91.36 High High
Morphine 2 88.40 High High
Nav1.2 88 82.48 Quite High
opiate 2 78.32 Quite High
tolerance 8 77.76 Quite High
addiction 5 76.64 Quite High
Somatostatin 1 74.28 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 468 99.56 Very High Very High Very High
Poisoning 39 99.52 Very High Very High Very High
Sprains And Strains 69 99.16 Very High Very High Very High
Stress 250 99.12 Very High Very High Very High
Hepatotoxicity 49 98.66 Very High Very High Very High
Shock 31 98.36 Very High Very High Very High
Toxicity 43 98.32 Very High Very High Very High
Nicotine Addiction 68 95.52 Very High Very High Very High
Depression 19 94.60 High High
Targeted Disruption 193 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of PEITC on the expression of hepatic glutathione S-transferases (GST) and the glutathione (GSH) conjugation has been investigated in the Sprague-Dawley rat, and it has been determined whether hepatotoxicity of acetaminophen (AA) could be inhibited through the induction of GST expression in mouse. 2.
Gene_expression (expression) of GST associated with paracetamol and hepatotoxicity
1) Confidence 0.78 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.17 Pain Relevance 0.33
The effect of PEITC on the expression of hepatic glutathione S-transferases (GST) and the glutathione (GSH) conjugation has been investigated in the Sprague-Dawley rat, and it has been determined whether hepatotoxicity of acetaminophen (AA) could be inhibited through the induction of GST expression in mouse. 2.
Gene_expression (expression) of GST associated with paracetamol and hepatotoxicity
2) Confidence 0.78 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.17 Pain Relevance 0.26
There was no evidence that the absence of GSTP in null animals resulted in enhanced expression of other GST isoforms in the null mice (GST alpha, 1.48%, GST mu, 1.68% of resolved proteins) compared with the wild-type animals (GST alpha, 1.50%, GST mu, 1.40%).
Gene_expression (expression) of GST
3) Confidence 0.66 Published 2003 Journal Proteomics Section Abstract Doc Link 12601812 Disease Relevance 0.28 Pain Relevance 0.20
Perhaps, it is in part due to gender-dependent Gst pi expression.
Gene_expression (expression) of Gst
4) Confidence 0.49 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.42 Pain Relevance 0.95
Furthermore, hepatocyte RXRalpha deficiency altered the gene expression profile of the glutathione S-transferase (Gst) family.
Gene_expression (expression) of Gst in hepatocyte
5) Confidence 0.46 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16157696 Disease Relevance 0.23 Pain Relevance 1.04
However, significant gender-related differences in the expression of glutathione S-transferases (GST) have been observed in mice, with female mice expressing significantly more of this antioxidant than male mice [30].
Gene_expression (expression) of GST
6) Confidence 0.46 Published 2001 Journal BMC Physiol Section Body Doc Link PMC35354 Disease Relevance 0.50 Pain Relevance 0.18
However, the mechanism underlying the association between reduction in Gst pi expression and hepatoprotective effect against APAP toxicity remains to be further explored.
Gene_expression (expression) of Gst associated with toxicity and paracetamol
7) Confidence 0.43 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.51 Pain Relevance 0.87
To investigate the function of ssCRE-BP in the brain, recombinant glutathione-S-transferase (GST) fusion proteins containing ssCRE-BP were expressed in bacterial systems.
Gene_expression (expressed) of GST in brain
8) Confidence 0.42 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8959022 Disease Relevance 0 Pain Relevance 0.40
Basal expression of 13 of 15 Gst genes studied was altered in hepatocyte-specific RXRalpha-deficient mice.
Gene_expression (expression) of Gst in hepatocyte
9) Confidence 0.36 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16157696 Disease Relevance 0.22 Pain Relevance 1.03
In mice, isoproterenol-induced oxidative stress may be attenuated in females due to higher levels of GST [31].


Gene_expression (levels) of GST associated with stress
10) Confidence 0.35 Published 2001 Journal BMC Physiol Section Body Doc Link PMC35354 Disease Relevance 0.46 Pain Relevance 0.16
GST activities
Gene_expression (activities) of GST
11) Confidence 0.32 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0.08 Pain Relevance 0
Protein treatment prior to GalN intoxication caused an elevation in GST activity (3.35 ± 0.09 ?
Gene_expression (activity) of GST associated with poisoning
12) Confidence 0.32 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0.10 Pain Relevance 0
A decreased GST activity was observed in toxin control (1.16 ± 0.03 ?
Gene_expression (activity) of GST
13) Confidence 0.32 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0.09 Pain Relevance 0
-glutamyl transpeptidase, GPX glutathione peroxidase, GR glutathione reductase, GST glutathione-S-transferase, GSSG glutathione disulfideFigure 3Heat shock protein 70 protein levels in kidney tissues from Ames dwarf and wild-type mice at 3, 12, and 24 months of age.
Gene_expression (glutathione-S-transferase) of GST in kidney associated with shock
14) Confidence 0.28 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.50 Pain Relevance 0
Hepatic expression of mRNA for several GST genes is significantly elevated in dwarf mice over those of wild-type mice (GSTm1, GSTm3, GSTp2, GSTa2, GSTa4; Tsuchiya et al. 2004).
Gene_expression (expression) of GST
15) Confidence 0.25 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.30 Pain Relevance 0
The supernatant containing secreted GST-mNT5E was filtered (0.45 ?
Gene_expression (containing) of GST
16) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0
The GST-Sox17 and GST-Smad3 fusion proteins (and GST only) were expressed in BL21 cells induced with 1 mM isopropyl ?
Gene_expression (expressed) of GST
17) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.06 Pain Relevance 0
The GST-Sox17 and GST-Smad3 fusion proteins (and GST only) were expressed in BL21 cells induced with 1 mM isopropyl ?
Gene_expression (expressed) of GST
18) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.06 Pain Relevance 0
The GST-Sox17 and GST-Smad3 fusion proteins (and GST only) were expressed in BL21 cells induced with 1 mM isopropyl ?
Gene_expression (expressed) of GST
19) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.06 Pain Relevance 0
GST pulldowns
Gene_expression (pulldowns) of GST
20) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.06 Pain Relevance 0

General Comments

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