INT31599

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.35
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mgst1) endoplasmic reticulum (Mgst1) nucleus (Mgst1)
Anatomy Link Frequency
liver 3
kidney 2
cleavage 1
spleen 1
nodules 1
Mgst1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 21 98.22 Very High Very High Very High
qutenza 2 93.04 High High
agonist 20 75.92 Quite High
Inflammation 17 73.28 Quite High
Pain 4 72.24 Quite High
adenocard 30 50.00 Quite Low
Antinociceptive 22 50.00 Quite Low
Potency 1 18.56 Low Low
antagonist 1 14.92 Low Low
depression 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Poisoning 39 99.44 Very High Very High Very High
Body Weight 52 97.56 Very High Very High Very High
Infection 124 94.40 High High
Weight Gain 1 94.16 High High
Cancer 58 91.80 High High
Liver Failure 3 91.48 High High
Renal Disease 12 91.20 High High
Malaria 90 89.88 High High
Renal Failure 27 89.64 High High
Colon Cancer 9 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paracetamol (acetaminophen) 90-150 mg.kg-1 increased the activity of serum glutathione S-transferase (GST) and yet reduced the activities of liver microsomal and homogenate GST in mice.
Negative_regulation (reduced) of GST in liver associated with paracetamol
1) Confidence 0.59 Published 1993 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 8010073 Disease Relevance 0 Pain Relevance 0.49
Furthermore, it has been determined that cytosolic glutathione S-transferase (GST) activity was decreased and glutathione peroxidase (GSH-Px) activity remained unchanged.
Negative_regulation (decreased) of GST
2) Confidence 0.54 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7963244 Disease Relevance 0 Pain Relevance 0.17
In addition, pretreatment with AC significantly prevented both the depletion of reduced glutathione (GSH) content and the decrease in glutathione-S-transferase (GST) activity in the liver of CCl4-intoxicated mice.
Negative_regulation (decrease) of GST in liver
3) Confidence 0.41 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 18984026 Disease Relevance 0.46 Pain Relevance 0.11
A decreased GST activity was observed in toxin control (1.16 ± 0.03 ?
Negative_regulation (decreased) of GST
4) Confidence 0.20 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0.09 Pain Relevance 0
The extent of lipid peroxidation and the level of GSSG were also enhanced by the GalN intoxication whereas the activities of antioxidant enzymes SOD, CAT, GR and GST as well as the levels of total thiols and GSH were decreased in the kidney tissue homogenates.
Negative_regulation (decreased) of GST in kidney associated with poisoning
5) Confidence 0.20 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1868763 Disease Relevance 0.72 Pain Relevance 0
In the present study we found that GalN administration at a dose of 800 mg/kg body weight for three days caused enhanced oxidative insult in the kidney tissue as evidenced by the increased renal TBARS level and depletion in the activities of endogenous antioxidant enzymes such as SOD, CAT, GR and GST.
Negative_regulation (depletion) of GST in kidney associated with body weight
6) Confidence 0.18 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 1.04 Pain Relevance 0
The administration of growth hormone opposes the beneficial effects of this pathway by downregulating GST and upregulating GGT activities (Brown-Borg et al. 2005).
Negative_regulation (downregulating) of GST
7) Confidence 0.16 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.48 Pain Relevance 0
Our construct was otherwise identical to the one used by Servos and colleagues--our construct contained a gp67 signal peptide, glutathione S-transferase (GST), a thrombin cleavage site to permit removal of GST and a C-terminal hexahistidine (His)6 tag (Figure 1A).
Negative_regulation (removal) of GST in cleavage
8) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0
The authors found a decline of microsomal and cytosolic GST activities in the liver and spleen of infected mice that were to some extent reversed by treatment with mefloquine and menadione.
Negative_regulation (decline) of GST in spleen
9) Confidence 0.10 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.74 Pain Relevance 0.13
The only phase II-associated enzyme altered by age was GST activity, as sedentary middle-aged animals exhibited a 43% decrease in activity when compared with young rats.
Negative_regulation (decrease) of GST
10) Confidence 0.05 Published 1993 Journal Drug Metab. Dispos. Section Abstract Doc Link 8100504 Disease Relevance 0.09 Pain Relevance 0.19
transcription of detoxification enzymes glutathione S-transferases (GST) which are known to protect cells from
Negative_regulation (known) of GST
11) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 0.71 Pain Relevance 0.25
The authors found a decline of microsomal and cytosolic GST activities in the liver and spleen of infected mice that were to some extent reversed by treatment with mefloquine and menadione.
Negative_regulation (decline) of GST in liver
12) Confidence 0.03 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.74 Pain Relevance 0.13
These latter three compounds have been shown to inhibit hepatocarcinogenesis after initial treatment with N-ethyl-N-hydroxyethylnitrosamine (EHEN) and a significant decrease in the number of enzyme-altered foci and nodules positive for GST-P, GST-A, G6PD and gamma-GT and negative for P-450 PB3a, P-450 MC2 was associated with their administration.
Negative_regulation (decrease) of GST in nodules
13) Confidence 0.02 Published 1988 Journal Carcinogenesis Section Abstract Doc Link 2895690 Disease Relevance 0.06 Pain Relevance 0.26
The altered balance of the antioxidant enzymes caused by decrease in CAT, SOD, GPx, GST and GSH activities may be responsible for the inadequacy of the antioxidant defenses in combating ROS mediated damage.
Negative_regulation (decrease) of GST
14) Confidence 0.01 Published 2004 Journal BMC Complement Altern Med Section Body Doc Link PMC533881 Disease Relevance 0.22 Pain Relevance 0

General Comments

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