INT316010

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 1.47
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
articulation 1
nodes 1
ANS 1
autonomic 1
cortex 1
AIC (Homo sapiens)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 541 100.00 Very High Very High Very High
Autonomic response 116 99.68 Very High Very High Very High
Pain 139 94.92 High High
Somatosensory cortex 35 89.44 High High
medulla 16 82.08 Quite High
insula 164 81.84 Quite High
Periaqueductal grey 9 79.72 Quite High
positron emission tomography 27 77.40 Quite High
Thalamus 10 74.92 Quite High
amygdala 9 74.04 Quite High
Disease Link Frequency Relevance Heat
Blindness 56 97.08 Very High Very High Very High
Pain 121 94.92 High High
Urological Neuroanatomy 30 79.72 Quite High
Mutism 3 70.72 Quite High
Aggression 6 64.36 Quite High
Mental Disorders 3 63.44 Quite High
Akinetic Mutism 6 45.80 Quite Low
Autism 10 41.76 Quite Low
Cognitive Disorder 151 41.12 Quite Low
Mixed Anxiety And Depression 3 40.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In view of our theme of ACC–AIC interaction, it should also be noted that a number of studies of speech production in humans have highlighted the left AIC as being involved in the preparation and co-ordination of articulation and phonation (Blank et al. 2002; Ackermann and Riecker 2004; Riecker et al. 2005).
AIC Binding (interaction) of in articulation associated with anterior cingulate cortex
1) Confidence 0.42 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886906 Disease Relevance 0.28 Pain Relevance 0.38
AIC and adjacent orbitofrontal/frontoopercular cortex has been found to be engaged selectively to aware errors, whereas the error-related RZC activity shows no significant difference between unaware and aware errors (Hester et al. 2005; Klein et al. 2007).
AIC Binding (engaged) of in cortex
2) Confidence 0.41 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0.10 Pain Relevance 0.04
It is far from clear, however, what precise association the AIC and the ANS share.
AIC Spec (clear) Binding (association) of in ANS
3) Confidence 0.41 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0.07 Pain Relevance 0.04
As already discussed in Klein et al. (2007), it is unclear whether (a) AIC activity precedes and causes the ANS response, (b) the ANS response elicits the AIC engagement by interoception, or (c) both occur simultaneously.
AIC Binding (engagement) of
4) Confidence 0.41 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0.09 Pain Relevance 0.04
This is consistent with our proposed overall scheme of AIC and ACC function.


AIC Spec (proposed) Binding (scheme) of associated with anterior cingulate cortex
5) Confidence 0.32 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886906 Disease Relevance 0.60 Pain Relevance 1.21
Importantly, these indices of ANS have earlier been demonstrated to be associated with activity in both the RCZ and the AIC (Critchley et al. 2005a, b; Medford and Critchley 2010, this issue).
AIC Binding (associated) of
6) Confidence 0.32 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0.10 Pain Relevance 0.03
Likewise, preparatory pupil diameter predicts functional connectivity of AIC with nodes of the attention/control networks (S, IPS) increased at the expense of functional connectivity with nodes of the default mode network (aMPFC)
AIC Binding (connectivity) of in nodes
7) Confidence 0.32 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0.08 Pain Relevance 0.03
The AIC and its relation to the autonomic response appear to be crucial for error awareness.
AIC Binding (relation) of in autonomic associated with autonomic response
8) Confidence 0.32 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0 Pain Relevance 0.14
A perspective on integrating the AIC, the ANS, and error awareness: the orienting response account
AIC Binding (integrating) of
9) Confidence 0.32 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0.09 Pain Relevance 0.03
More specific evidence of functional interaction between ACC and AIC comes from a study by Sridharan et al. (2008), which identified a fronto-insular cingulate system involved in switching between default mode and central executive networks.
AIC Binding (interaction) of associated with anterior cingulate cortex
10) Confidence 0.31 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886906 Disease Relevance 0.08 Pain Relevance 0.46

General Comments

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