INT316040

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.57
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ncor2) DNA binding (Ncor2)
Anatomy Link Frequency
thyroid 3
Ncor2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 2 60.08 Quite High
Inflammation 73 41.84 Quite Low
interneuron 1 14.28 Low Low
medulla 1 12.96 Low Low
Hippocampus 6 10.12 Low Low
Pyramidal cell 1 9.36 Low Low
cINOD 39 5.00 Very Low Very Low Very Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
agonist 14 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 21 82.96 Quite High
Neurodegenerative Disease 5 77.00 Quite High
Disease 150 66.00 Quite High
Frontotemporal Dementia 8 65.04 Quite High
Nervous System Malformation 1 60.56 Quite High
Obesity 153 55.12 Quite High
Repression 4 42.96 Quite Low
INFLAMMATION 93 41.84 Quite Low
Hypoxia 5 29.64 Quite Low
Brain Injury 3 29.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-secretase releases the intracellular domain of ErbB4 (Ni et al., 2001), which then binds to TAB2 and the corepressor N-CoR (Sardi et al., 2006).
Localization (releases) of N-CoR
1) Confidence 0.28 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.41 Pain Relevance 0.03
recruits corepressors such as silencing mediator for retinoic and thyroid hormone receptors (SMRT) and the nuclear receptor corepressor (N-Cor), which bind repressive enzymes such as histone deacetylase enzymes (HDAC), and particularly HDAC3 [43] or the histone methyl transferase (HMT) SUV39H1, which specifically methylates histone H3 at lysine 9 (H3K9) [44].
Localization (retinoic) of N-Cor in thyroid
2) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.05 Pain Relevance 0
recruits corepressors such as silencing mediator for retinoic and thyroid hormone receptors (SMRT) and the nuclear receptor corepressor (N-Cor), which bind repressive enzymes such as histone deacetylase enzymes (HDAC), and particularly HDAC3 [43] or the histone methyl transferase (HMT) SUV39H1, which specifically methylates histone H3 at lysine 9 (H3K9) [44].
Localization (retinoic) of SMRT in thyroid
3) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.05 Pain Relevance 0
recruits corepressors such as silencing mediator for retinoic and thyroid hormone receptors (SMRT) and the nuclear receptor corepressor (N-Cor), which bind repressive enzymes such as histone deacetylase enzymes (HDAC), and particularly HDAC3 [43] or the histone methyl transferase (HMT) SUV39H1, which specifically methylates histone H3 at lysine 9 (H3K9) [44].
Localization (recruits) of SMRT in thyroid
4) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.06 Pain Relevance 0

General Comments

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