INT316041

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Context Info
Confidence 0.64
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.10
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Psen2) endoplasmic reticulum (Psen2) embryo development (Psen2)
protein complex (Psen2) cytosol (Psen2) peptidase activity (Psen2)
Anatomy Link Frequency
astrocytes 1
cortex 1
Psen2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 18 99.24 Very High Very High Very High
interneuron 3 95.84 Very High Very High Very High
medulla 3 94.52 High High
Pyramidal cell 3 90.92 High High
Inflammatory response 42 30.04 Quite Low
Inflammation 129 25.68 Quite Low
Central nervous system 6 20.24 Low Low
cINOD 108 8.88 Low Low
cytokine 27 5.00 Very Low Very Low Very Low
Eae 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 12 94.48 High High
Apoptosis 6 94.04 High High
Amyloid Plaque 33 91.84 High High
Targeted Disruption 54 88.96 High High
Disease 243 81.60 Quite High
Brain Injury 9 81.28 Quite High
Hypoxia 15 79.92 Quite High
Frontotemporal Dementia 24 70.88 Quite High
Brain Disease 12 30.76 Quite Low
INFLAMMATION 180 29.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although PS are mainly expressed in neurons, PS1 and PS2 mRNAs are detected at low levels in white matter glial cells and cultured astrocytes (Lee et al., 1996).
Transcription (detected) of PS2 in astrocytes
1) Confidence 0.64 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.24 Pain Relevance 0.23
By contrast, PS1 and PS2 mRNAs are highly expressed in neurons of the hippocampus and entorhinal cortex in adult mouse brain (Lee et al., 1996).
Transcription (expressed) of PS2 in cortex associated with hippocampus
2) Confidence 0.50 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0 Pain Relevance 0.22
production in cells derived from PS1 and PS1/PS2 deficient mice (De Strooper et al., 1998; Zhang et al., 2000) and the absence of A?
Transcription (derived) of PS2
3) Confidence 0.28 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.86 Pain Relevance 0

General Comments

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