INT316054

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.78
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6) translation (Eif1)
Anatomy Link Frequency
Monocyte 1
Eif1 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 43 81.44 Quite High
cytokine 9 80.40 Quite High
chemokine 3 59.60 Quite High
Eae 3 44.24 Quite Low
Hippocampus 6 25.44 Quite Low
cINOD 36 5.00 Very Low Very Low Very Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 81 100.00 Very High Very High Very High
Alzheimer's Dementia 9 93.20 High High
INFLAMMATION 60 81.44 Quite High
Amyloid Plaque 11 57.76 Quite High
Death 4 52.48 Quite High
Dementia 14 50.20 Quite High
Cognitive Disorder 13 49.20 Quite Low
Encephalitis 1 46.48 Quite Low
Aging 2 35.44 Quite Low
Neurological Disease 1 33.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) are increased by familial AD-linked PS mutations (Sokolova et al., 2009), and mutant PS1 enhances expression of microglial factors that promote differentiation of neural precursor cells into glial fibrillary acidic protein (GFAP)-positive cells (Choi et al., 2008).
mutations Positive_regulation (increased) of interleukin-6 in Monocyte associated with disease
1) Confidence 0.00 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.78 Pain Relevance 0.21

General Comments

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