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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.77
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
Monocyte 1
Ps (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 43 80.64 Quite High
cytokine 9 79.60 Quite High
chemokine 3 58.80 Quite High
Eae 3 44.24 Quite Low
Hippocampus 6 24.64 Low Low
cINOD 36 5.00 Very Low Very Low Very Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 81 100.00 Very High Very High Very High
Alzheimer's Dementia 9 93.20 High High
INFLAMMATION 60 80.64 Quite High
Amyloid Plaque 11 57.76 Quite High
Death 4 51.68 Quite High
Dementia 14 50.20 Quite High
Cognitive Disorder 13 49.20 Quite Low
Encephalitis 1 46.48 Quite Low
Aging 2 34.64 Quite Low
Neurological Disease 1 32.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) are increased by familial AD-linked PS mutations (Sokolova et al., 2009), and mutant PS1 enhances expression of microglial factors that promote differentiation of neural precursor cells into glial fibrillary acidic protein (GFAP)-positive cells (Choi et al., 2008).
PS Positive_regulation (increased) of interleukin-6 in Monocyte associated with disease
1) Confidence 0.04 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.77 Pain Relevance 0.21

General Comments

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